PRKCB Research Reagents

Protein kinase C beta type is a protein in humans that is encoded by PRKCB gene. Calcium-activated, phospholipid and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1.

The following PRKCB reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

PRKCB Antibodies

PRKCB Antibodies for Homo sapiens (Human)

PRKCB Proteins

PRKCB Proteins for Mus musculus (Mouse)

PRKCB Proteins for Oryctolagus cuniculus (Rabbit)

PRKCB Proteins for Bos taurus (Bovine)

PRKCB Proteins for Homo sapiens (Human)

PRKCB Proteins for Rattus norvegicus (Rat)

PRKCB Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

PRKCB Proteins for Xenopus laevis (African clawed frog)

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