PTGES3

PTGES3 encodes Prostaglandin E Synthase 3, commonly known as p23—a conserved cytosolic co-chaperone protein. It forms a core component of the heat shock protein 90 (Hsp90) chaperone complex, stabilizing Hsp90’s ATPase domain to enhance client protein folding, maturation, and functional activation.
PTGES3-mediated Hsp90 signaling regulates key oncoproteins (e.g., EGFR, HER2, Akt) and links to cancer progression (breast, prostate, lung malignancies). Preclinical studies explore small molecules targeting p23-Hsp90 interactions to disrupt oncogenic pathways, though no therapeutic agents are clinically approved to date.