RAB32

RAB32, or Ras-associated protein Rab-32, alias RAB32_HUMAN.RAB32 is a small G protein, a member of the RAS oncogene family, located on human chromosome 17. It is an important G protein-coupled receptor (GPCR) that plays a role in intracellular signaling and a variety of biological processes.The mechanism of action of RAB32 involves the regulation of intracellular signaling pathways, particularly through activation of the protein kinase CKG pathway, which affects tumor cell growth, invasion, and metastasis.RAB32 is also involved in cell adhesion and in helping tumor cells to evade immune surveillance, and these functions play a key role in tumor development and metastasis.

The biological significance of RAB32 is mainly reflected in its potential as a drug target and biomarker. In a variety of tumors, especially lung cancer and hepatocellular carcinoma, the expression level of RAB32 is positively correlated with the invasiveness and metastatic ability of tumors, making it an important biomarker for tumor therapy and prognostic judgment.Activators of RAB32, such as belantamab, have been investigated for the inhibition of tumor cell growth and metastasis, demonstrating its potential in tumor therapy. In addition, the detection of RAB32 expression levels can provide guidance for personalized treatment of tumor patients, which can help predict patient survival and guide clinical treatment decisions.