ROR1

ROR1, or Receptor Tyrosine Kinase-like Orphan Receptor 1, also known as Neurotrophic Tyrosine Kinase, Receptor-related 1, is a Type I transmembrane protein and a member of the Receptor Tyrosine Kinases (RTKs) family. ROR1 is either lowly expressed or not expressed in normal human tissues but is highly expressed in a variety of malignant tumors or tissues, such as Chronic Lymphocytic Leukemia (CLL), breast cancer, ovarian cancer, melanoma, lung adenocarcinoma, and others. The mechanism of action of ROR1 involves mediating the non-canonical Wnt signaling pathway, particularly Wnt5a, participating in the phosphorylation of the NF-κB subunit p65, activating the NF-κB pathway in tumor cells, and promoting cell migration and invasion. As a highly specific tumor-associated antigen, ROR1 has become a potentially attractive target in cancer therapy.