ROR1 is a transmembrane receptor tyrosine kinase protein, and the gene encoding ROR1 is located on chromosome 1p31.3. The structure of ROR1 is highly conserved among various species, for example, the amino acid sequence homology of ROR1 between human and mouse can reach 97%.
ROR1 plays an important role in a variety of physiological processes by mediating signaling through non-canonical Wnt pathways, including regulation of cell division, proliferation, migration, and cell chemotaxis, especially Wnt5a/ROR1 signaling pathway. Wnt5a is a typical activator of non-canonical Wnt signaling pathway. It participates in the phosphorylation of NF-κB subunit p65, activates the NF-κB pathway in tumor cells, and promotes cell migration and invasion, EMT, and cancer metastasis. Wnt5a/ROR1 is highly expressed in various cancers. As a receptor for Wnt5a, ROR1 is involved in activating the NF-κB pathway in tumor cells. The NF-κB pathway is at the helm of inflammatory responses and immune regulation and is constitutively activated in multiple tumor types.
Recombinant Human Inactive tyrosine-protein kinase transmembrane receptor ROR1(ROR1),partial (Active) (CSB-MP020067HU1d7)
Greater than 95% as determined by SDS-PAGE.
The binding activity of antigen-antibody validated by functional ELISA
Immobilized ROR1 at 2 μg/ml can bind anti-ROR1 antibody (CSB-RA020067A1HU), the EC50 is 0.2450-0.3416 ng/mL.
The following ROR1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.