Ror1, also known as Receptor tyrosine kinase-like orphan receptor 1, is a protein with various aliases like Neurotrophic tyrosine kinase, receptor-related 1. This protein is a transmembrane receptor that belongs to the receptor tyrosine kinase family. It plays a key role in cell survival, migration, and differentiation through Wnt signaling pathway.
Ror1 has been associated with several diseases, including leukemia and solid tumors. It is regarded as a potential therapeutic target. Some novel drugs targeting Ror1 are in different stages of pre - clinical and clinical trials, aiming to block its function and inhibit tumor progression.
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized ROR1 at 2 μg/ml can bind anti-ROR1 antibody(CSB-RA020067A1HU), the EC50 is 0.2450-0.3416 ng/mL.
The purity of ROR1 was greater than 90% as determined by SEC-HPLC
ROR1 Recombinant Monoclonal Antibody (CSB-RA020067A1HU)
Validated Data
The Binding Activity of ROR1 with Anti-ROR1 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human ROR1(CSB-MP020067HU1d7) at 2 μg/mL can bind Anti-ROR1 recombinant antibody, the EC50 is 0.2450-0.3416 ng/mL.
Untransfected CT26 cells (green line) and transfected Human ROR1 CT26 stable cells (red line) were stained with anti-ROR1 antibody (2µg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
ROR1 Antibody (CSB-PA020067LA01HU)
Validated Data
Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA020067LA01HU at dilution of 1:10
The following ROR1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
ROR1 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA020067LC01HU | ROR1 Antibody, FITC conjugated | Human | |
CSB-PA020067LA01HU | ROR1 Antibody | Human | ELISA, IHC |
CSB-PA020067GA01HU | ROR1 Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA067964 | ROR1 Antibody | Human,Mouse | ELISA,IHC |
CSB-PA993257 | ROR1 Antibody | Human,Mouse | ELISA,IHC |
CSB-RA020067A1HU | ROR1 Recombinant Monoclonal Antibody | Human | ELISA, FC |
ROR1 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP020067HU | Recombinant Human Tyrosine-protein kinase transmembrane receptor ROR1 (ROR1), partial | Yeast |
CSB-EP020067HU | Recombinant Human Tyrosine-protein kinase transmembrane receptor ROR1 (ROR1), partial | E.coli |
CSB-MP020067HU CSB-EP020067HU-B |
Recombinant Human Tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) | Mammalian cell In Vivo Biotinylation in E.coli |
CSB-MP020067HU1d7 | Recombinant Human Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1), partial (Active) | Mammalian cell |