RPA2

Replication protein A 32 kDa subunit is a protein in humans that is encoded by RPA2 gene. As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage.

RPA2 Antibodies

RPA2 Antibodies for Homo sapiens (Human)

RPA2 Antibodies for Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)

RPA2 Antibodies for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

RPA2 Proteins

RPA2 Proteins for Homo sapiens (Human)

RPA2 Proteins for Euplotes octocarinatus

RPA2 Proteins for Crithidia fasciculata

RPA2 Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

RPA2 Proteins for Mus musculus (Mouse)

RPA2 Proteins for Rattus norvegicus (Rat)

RPA2 Proteins for Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)

RPA2 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

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