S-phase kinase-associated protein 2 is a protein in humans that is encoded by SKP2 gene. Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration.
The following SKP2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
SKP2 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA021362GA01HU | SKP2 Antibody |
Human,Mouse,Rat | ELISA,WB |
CSB-PA613392LA01HU | SKP2 Antibody |
Human | ELISA, WB, IHC |
CSB-PA613392LD01HU | SKP2 Antibody, Biotin conjugated |
Human | ELISA |
CSB-PA004098 | SKP2 Antibody |
Human | WB, IHC, IF, ELISA |
CSB-RA155372A0HU | SKP2 Recombinant Monoclonal Antibody |
Human | ELISA, IF, FC |
CSB-RA224072A0HU | SKP2 Recombinant Monoclonal Antibody |
Human | ELISA, IHC, IF |
SKP2 Antibodies for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA331655XA01SVG | SKP2 Antibody |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | ELISA, WB (ensure identification of antigen) |
SKP2 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Code | Product Name | Source |
---|---|---|
CSB-YP331655SVG CSB-EP331655SVG CSB-BP331655SVG CSB-MP331655SVG CSB-EP331655SVG-B |
Recombinant Saccharomyces cerevisiae F-box protein SKP2 (SKP2), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SKP2 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-EP613392HU | Recombinant Human S-phase kinase-associated protein 2 (SKP2) |
E.coli |
CSB-YP613392HU CSB-BP613392HU CSB-MP613392HU CSB-EP613392HU-B |
Recombinant Human S-phase kinase-associated protein 2 (SKP2) |
Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |