SRF

Serum Response Factor (SRF), also called c-fos serum response element-binding protein, is a transcription factor that binds to the serum response element (SRE) in target gene promoters. It regulates genes involved in cell proliferation, differentiation, and cytoskeletal remodeling, such as c-fos and actin family members.
SRF participates in MAPK/ERK (phosphorylated Elk-1 complexes with SRF for transcription activation) and actin pathways. Its dysregulation links to cardiovascular diseases (atherosclerosis, myocardial hypertrophy) and cancers (lung, breast). Preclinical inhibitors targeting SRF-ELK1 interactions exist, but none have entered clinical trials.