SSX2

The SSX2 protein, also known as SSX family member 2, is a nuclear protein that functions as a transcriptional repressor. It is commonly associated with synovial sarcoma, a soft tissue cancer, due to its involvement in chromosomal translocations. SSX2 interacts with polycomb transcription repression complexes, regulating gene expression. It is involved in several signaling pathways, including the Ephrin/Eph system, which plays a role in cell positioning and migration. SSX2 is also implicated in the development of breast cancer and other malignancies, and its dysregulation is associated with metastatic potential. Research on SSX2 is ongoing, with potential therapeutic targets identified for cancer treatment.