SUB1

The SUB1 gene encodes Positive Cofactor 4 (PC4), also known as transcriptional coactivator p15. It functions as a nuclear cofactor supporting RNA polymerase II-mediated transcription initiation/elongation, chromatin remodeling, and DNA repair. PC4 interacts with p53 and AP-1 to regulate target gene expression, critical for cell proliferation and stress responses.
Aberrant SUB1 expression links to lung, colorectal, and breast cancers, promoting tumorigenesis via activating PI3K/Akt and MAPK pathways. Preclinical research explores small-molecule inhibitors targeting PC4’s coactivator activity; in vitro studies show such inhibitors suppress cancer cell growth and migration, holding potential for anti-tumor therapy.