TACSTD2 (tumor-associated calcium signal transduction 2), a member of TACSTD family, is a type I transmembrane glycoprotein encoded by TACSTD2 gene, is also known as TROP2, GA733-1 or M1S1.
TROP2 represents a new cell surface receptor and plays a role in regulating the growth of tumor cells. TROP2 is over-expressed in many kinds of malignant tumors, and it is an oncogene related to the occurrence, invasion and metastasis of malignant tumors.
Acting as a signaling molecule, TROP2 regulates tumor cell growth and shares homology with serum IGF-II binding protein. It functions as a glycoprotein receptor on epithelial membranes, participating in intracellular calcium signaling.
TROP2 has a regulatory role in cell renewal, proliferation, and transformation, promoting tumor growth, while its absence disrupts tumor cell proliferation. Moreover, TROP2 plays crucial roles in embryonic development, including embryo implantation, placental tissue formation, embryonic stem cell proliferation, and organ development.
As a transmembrane protein, TROP2 is overexpressed in a variety of tumors, so it can be used as a natural candidate for the development of targeted therapy. In addition, the limitation of its tissue expression reduces its therapeutic toxicity.
At present, the research targeting TROP2 has been carried out in solid tumor, gastric cancer, breast cancer, triple negative breast cancer, small cell lung cancer, non-small cell lung cancer, pancreatic cancer, urogenital system cancer, prostate cancer and other diseases.
The drug Sacituzumab govitecan for urogenital system cancer, prostate cancer, breast cancer, solid tumor research (IMMU-132) has been in the BLA application stage.
111In-IMP-288 for cancer is currently in phase II.
SKB-264 for solid tumours SKB-264 is currently in phase II.
BAT8003 for breast cancer is currently in phase Ⅰ.
DS-1062 for non small cell lung cancer (NSCLC) is currently in phase Ⅰ.
Read more: TROP2-An Important Target for Cancer Treatment
Validated Data
Greater than 90% as determined by SDS-PAGE.
Measured in cell activity assay using U937 cells, the EC50 for this effect is 190.2-298.6 ng/ml.
● TROP2 Recombinant Monoclonal Antibody (CSB-RA023072MA1HU)
Validated Data
Measured by its binding ability in a functional ELISA. Immobilized Human TROP2 (CSB-MP023072HU1d7) at 2 μg/mL can bind Anti-TROP2 recombinant antibody, the EC50 is 0.7284-1.075 ng/mL.
Measured by its binding ability in a functional ELISA. Immobilized Human TROP2 (CSB-MP023072HU2) at 2 μg/mL can bind Anti-TROP2 recombinant antibody, the EC50 is 0.9108-1.640 ng/mL.
The following TACSTD2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
TACSTD2 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA170174 | TACSTD2 Antibody |
Human,Mouse,Rat | ELISA,WB |
CSB-PA023072ESR1HU | TACSTD2 Antibody |
Human | ELISA, IHC |
CSB-PA004333 | TACSTD2 Antibody |
Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA830561 | TACSTD2 Antibody |
Human,Mouse,Rat | ELISA,IHC |
CSB-RA023072MA1HU | TROP2 Recombinant Monoclonal Antibody |
Human | ELISA |
TACSTD2 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP023072HU1 CSB-EP023072HU1 CSB-BP023072HU1 CSB-EP023072HU1-B |
Recombinant Human Tumor-associated calcium signal transducer 2 (TACSTD2), partial |
Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
CSB-CF023072HU | Recombinant Human Tumor-associated calcium signal transducer 2 (TACSTD2) |
in vitro E.coli expression system |
CSB-MP023072HU1 | Recombinant Human Tumor-associated calcium signal transducer 2 (TACSTD2), partial (Active) |
Mammalian cell |
CSB-MP023072HU | Recombinant Human Tumor-associated calcium signal transducer 2 (TACSTD2) |
Mammalian cell |
CSB-MP023072HU2 | Recombinant Human Tumor-associated calcium signal transducer 2 (TACSTD2), partial (Active) |
Mammalian cell |
CSB-MP023072HU1d7 | Recombinant Human Tumor-associated calcium signal transducer 2 (TACSTD2), partial (Active) |
Mammalian cell |
TACSTD2 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP023072RA CSB-EP023072RA CSB-BP023072RA CSB-MP023072RA CSB-EP023072RA-B |
Recombinant Rat Tumor-associated calcium signal transducer 2 (Tacstd2), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TACSTD2 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP023072MO CSB-EP023072MO CSB-BP023072MO CSB-MP023072MO CSB-EP023072MO-B |
Recombinant Mouse Tumor-associated calcium signal transducer 2 (Tacstd2), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |