TACSTD2

TACSTD2, tumor-associated calcium signal transducer 2, also known as TROP2, EGP-1, GA733-1, M1S1, etc., is encoded by the human TACSTD2 gene, which is located on chromosome 1 in the 1p32.1 region.TACSTD2 protein is a cell surface glycoprotein, a single transmembrane protein, consisting of 323 amino acids with a hydrophobic lead peptide, an extracellular structural domain, a transmembrane structural domain and a cytoplasmic tail.
The mechanism of action of TACSTD2 involves a highly conserved phosphatidylinositol 4,5-bisphosphate (PIP2)-binding sequence in its cytoplasmic tail, which plays an important role in signal transduction.TACSTD2 is involved in cellular signaling through its interaction with PIP2 and tyrosine and serine phosphorylation sites that affect cell cycle progression.
TACSTD2 is overexpressed in a variety of malignant tumors and is associated with tumorigenesis, invasion and metastasis.The degree of TACSTD2 expression correlates with the malignancy of the disease, and its overexpression promotes the growth, proliferation and metastasis of tumor cells, so it has become a new target for the development of antibody-coupled drugs.