Toll-like receptor 10 (TLR10) is mainly expressed on the surface of B cells and belongs to a type I transmembrane protein. It is the only orphan receptor in the TLRs family and has no known specific ligands. TLR10 shares 50% and 49% amino acid identity with TLR1 and TLR6, respectively, shares 30% homology with TLR2, and shares no more than 25% similarity with other members. The N-terminus of TLR10 protein is highly glycosylated and can form co-receptors with TLR1 and 2, and can also form homodimers with itself.
TLR10 is different from other members of the TLRs family in that it lacks the classical downstream signaling pathway. Although it can interact with MyD88 molecule, it cannot activate the transcription factor of TLR signaling pathway. Although the ligands and downstream signaling pathways of TLR10 are still unclear, some studies have pointed out that synthetic diacylated lipoproteins, lipopolysaccharides, flagellin, triacylated lipopeptides, and dsRNA may be the ligands of TLR10. TLR10 is an inhibitory receptor and a negative regulator of other TLR signaling, which can inhibit the production of inflammatory factors by TLR2 and play a role in inhibiting inflammation. The polymorphism of the N241H (rs11096957) locus of the TLR10 gene will affect the function of TLR10, resulting in a decrease in its ability to inhibit the production of inflammatory factors such as IL-1β, IL-8, and TNFα.
The following TLR10 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
TLR10 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA023600ESR2HU | TLR10 Antibody |
Human | ELISA, IHC |
TLR10 Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-YP023600BO CSB-EP023600BO CSB-BP023600BO CSB-MP023600BO CSB-EP023600BO-B |
Recombinant Bovine Toll-like receptor 10 (TLR10), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TLR10 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP023600HU CSB-EP023600HU CSB-BP023600HU CSB-MP023600HU CSB-EP023600HU-B |
Recombinant Human Toll-like receptor 10 (TLR10), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF023600HU | Recombinant Human Toll-like receptor 10 (TLR10), partial |
in vitro E.coli expression system |
CSB-CF023600HUb3 | Recombinant Human Toll-like receptor 10 (TLR10), partial |
in vitro E.coli expression system |