Vacuolar protein sorting-associated protein 4A is a protein in humans that is encoded by VPS4A gene. Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Involved in cytokinesis.
The following VPS4A reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
VPS4A Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA891974DSR2HU | VPS4A Antibody |
Human, Mouse, Rat | ELISA, WB, IHC |
VPS4A Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP745124RA CSB-EP745124RA CSB-BP745124RA CSB-MP745124RA CSB-EP745124RA-B |
Recombinant Rat Vacuolar protein sorting-associated protein 4A (Vps4a) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
VPS4A Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP823757MO CSB-EP823757MO CSB-BP823757MO CSB-MP823757MO CSB-EP823757MO-B |
Recombinant Mouse Vacuolar protein sorting-associated protein 4A (Vps4a) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
VPS4A Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP891974HU CSB-BP891974HU CSB-MP891974HU CSB-EP891974HU-B |
Recombinant Human Vacuolar protein sorting-associated protein 4A (VPS4A) |
Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |