YTHDF1

YTHDF1, part of the YTH domain family, is an essential reader of m6A-modified RNA, significantly contributing to mRNA metabolism through its binding to this modification. Its YTH domain's interaction with m6A-modified RNA can influence mRNA stability, translation efficiency, and subcellular localization. YTHDF1 is also implicated in several signaling pathways that are pivotal for tumor cell proliferation, metabolic reprogramming, and immune evasion. Aberrant YTHDF1 expression is associated with a spectrum of diseases, especially in the context of cancer where its overexpression is linked to poorer prognoses and resistance to chemo- and immunotherapies. Thus, YTHDF1 is being considered a potential therapeutic target and a novel biomarker in cancer treatment.