B cells, also known as B lymphocytes, are pluripotent stem cells derived from bone marrow. It is an important part of adaptive immunity. When mature B cells are stimulated by antigen, they can differentiate into plasma cells, synthesize antibodies, and exert humoral immunity. In addition, B cells can also be used as antigen-presenting cells to capture antigen and present it to T lymphocytes.
The B cell antigen receptor (BCR) is a complex composed of mIg (mlgM and mlgD) and Igα/Igβ. The former recognizes the antigen and the latter transduces the antigenic stimulation signal received by the BCR. BCR directly recognizes intact, natural protein antigens, polysaccharides or lipid antigens. The cellular processes mediated by B cell antigen receptors mainly include cell proliferation and apoptosis. Its abnormality can cause a lack of humoral immune response or autoimmunity.
B cell receptor (BCR) signaling pathway is an important signaling pathway for B cell survival. B cell receptor (BCR) on the surface of B cells can recognize foreign antigen signals and mediate a series of complex biological effects, including activation, proliferation and differentiation of B cells.
After BCR is linked to the antigen, three main protein tyrosine kinases (PTKs) -the SRC-family kinase LYN, SYK and the TEC-family kinase BTK are activated.
Overactivation of several key kinases in the BCR signaling pathway plays an important role in the occurrence, development and drug resistance of B-cell tumors. Downstream effectors of BCR signals (e.g. Phosphatidylinositol 3-kinase (PI3K) and phospholipase C-gamma 2 (PLC-gamma 2) results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes.
|NFKBIB||NFKBIB Antibody||NFKBIB Protein||NFKBIB cDNA||NFKBIB ELISA Kit|
|NFKBIE||NFKBIE Antibody||NFKBIE Protein||NFKBIE cDNA||NFKBIE ELISA Kit|
|NRAS||NRAS Antibody||NRAS Protein||NRAS cDNA||NRAS ELISA Kit|
|PIK3AP1||PIK3AP1 Antibody||PIK3AP1 Protein||PIK3AP1 cDNA||PIK3AP1 ELISA Kit|
|PIK3CA||PIK3CA Antibody||PIK3CA Protein||PIK3CA cDNA||PIK3CA ELISA Kit|
|PIK3CB||PIK3CB Antibody||PIK3CB Protein||PIK3CB cDNA||PIK3CB ELISA Kit|
|PIK3CD||PIK3CD Antibody||PIK3CD Protein||PIK3CD cDNA||PIK3CD ELISA Kit|
|PIK3R1||PIK3R1 Antibody||PIK3R1 Protein||PIK3R1 cDNA||PIK3R1 ELISA Kit|
|PIK3R2||PIK3R2 Antibody||PIK3R2 Protein||PIK3R2 cDNA||PIK3R2 ELISA Kit|
|PIK3R3||PIK3R3 Antibody||PIK3R3 Protein||PIK3R3 cDNA||PIK3R3 ELISA Kit|
|PLCG2||PLCG2 Antibody||PLCG2 Protein||PLCG2 cDNA||PLCG2 ELISA Kit|
|PPP3CA||PPP3CA Antibody||PPP3CA Protein||PPP3CA cDNA||PPP3CA ELISA Kit|
|PPP3CB||PPP3CB Antibody||PPP3CB Protein||PPP3CB cDNA||PPP3CB ELISA Kit|
|PPP3CC||PPP3CC Antibody||PPP3CC Protein||PPP3CC cDNA||PPP3CC ELISA Kit|
|PPP3R1||PPP3R1 Antibody||PPP3R1 Protein||PPP3R1 cDNA||PPP3R1 ELISA Kit|
|PPP3R2||PPP3R2 Antibody||PPP3R2 Protein||PPP3R2 cDNA||PPP3R2 ELISA Kit|
|PRKCB||PRKCB Antibody||PRKCB Protein||PRKCB cDNA||PRKCB ELISA Kit|
|PTPN6||PTPN6 Antibody||PTPN6 Protein||PTPN6 cDNA||PTPN6 ELISA Kit|
|RAC1||RAC1 Antibody||RAC1 Protein||RAC1 cDNA||RAC1 ELISA Kit|
|RAC2||RAC2 Antibody||RAC2 Protein||RAC2 cDNA||RAC2 ELISA Kit|