BLNK

B-cell linker protein is a protein in humans that is encoded by BLNK gene. Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.

BLNK Antibodies

BLNK Antibodies for Homo sapiens (Human)

BLNK Antibodies for Human

BLNK Proteins

BLNK Proteins for Rattus norvegicus (Rat)

BLNK Proteins for Homo sapiens (Human)

BLNK Proteins for Mus musculus (Mouse)

BLNK Proteins for Gallus gallus (Chicken)

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