F3

F3 is a transmembrane glycoprotein comprising 263 amino acids, initiates blood coagulation by binding to factor VII/VIIa. Acting as an "anchor" to the cell membrane, F3 localizes the coagulation process to the site of injury and activates factors IX and X, triggering the amplification loops of both the intrinsic and extrinsic pathways of thrombosis. Despite this, F3 and FⅦ lack procoagulant activity when present alone at physiological concentrations. Often associated with enhanced blood coagulation in cancer patients, F3's overexpression on tumor endothelial and cancer cells may contribute to thrombosis within tumor tissues. The elevated expression of F3 influences cellular behaviors such as proliferation, invasion, and metastasis, positioning it as a promising therapeutic target in oncology.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human TF at 2 μg/ml can bind Anti-TF recombinant antibody (CSB-RA007928MA2HU). The EC₅₀ is 1.434-1.635 ng/mL.

The purity of F3 was greater than 95% as determined by SEC-HPLC

Recombinant Human Serotransferrin(TF) (Active) (CSB-MP023412HU)

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized TFRC(CSB-MP3648HU)at 2μg/mL can bind Human TF，the EC₅₀ is 58.72-77.84 ng/mL.

Recombinant Macaca fascicularis Tissue factor (F3), partial (Active) (CSB-MP6582MOV)

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis F3 at 2 μg/ml can bind Anti-F3 recombinant antibody (CSB-RA007928MA2HU). The EC₅₀ is 0.4495-0.5538 ng/mL.

The following F3 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

F3 Antibodies

F3 Proteins

F3 ELISA Kits

F3 Antibodies

F3 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA007928LA01HU	F3 Antibody	Human, Mouse	ELISA, WB, IHC, IF
CSB-PA004263	F3 Antibody	Human,Monkey	WB, ELISA
CSB-PA005114	F3 Antibody	Human	WB, ELISA
CSB-PA008166	Phospho-F3 (S290) Antibody	Human	WB, IHC, ELISA
CSB-PA040718	F3 Antibody	Human	ELISA,WB,IHC
CSB-PA981490	F3 Antibody	Human	ELISA,IHC
CSB-RA776663A0HU	F3 Recombinant Monoclonal Antibody	Human, Rat	ELISA, WB, IHC

F3 Proteins

F3 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-BP007928HU1 CSB-MP007928HU1 CSB-EP007928HU1-B	Recombinant Human Tissue factor (F3), partial	Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF007928HU	Recombinant Human Tissue factor (F3)	in vitro E.coli expression system
CSB-EP007928HU1	Recombinant Human Tissue factor (F3), partial	E.coli
CSB-EP007928HU(F2)	Recombinant Human Tissue factor (F3)	E.coli
CSB-MP007928HU2	Recombinant Human Tissue factor (F3), partial (Active)	Mammalian cell
CSB-MP007928HU-WD	Recombinant Human Tissue factor (F3), partial	Mammalian cell

F3 Proteins for Microplitis demolitor bracovirus (isolate Webb) (MdBV)

Code	Product Name	Source
CSB-YP686307MDAK CSB-EP686307MDAK CSB-BP686307MDAK CSB-MP686307MDAK CSB-EP686307MDAK-B	Recombinant Microplitis demolitor bracovirus I-Kappa-B like protein F2 (F3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

F3 Proteins for Cavia porcellus (Guinea pig)

Code	Product Name	Source
CSB-YP888355GU CSB-EP888355GU CSB-BP888355GU CSB-MP888355GU CSB-EP888355GU-B	Recombinant Guinea pig Tissue factor (F3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

F3 Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-CF007928BO	Recombinant Bovine Tissue factor (F3)	in vitro E.coli expression system
CSB-YP007928BO1 CSB-EP007928BO1 CSB-BP007928BO1 CSB-MP007928BO1 CSB-EP007928BO1-B	Recombinant Bovine Tissue factor (F3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

F3 Proteins for Oryctolagus cuniculus (Rabbit)

Code	Product Name	Source
CSB-CF007928RB	Recombinant Rabbit Tissue factor (F3)	in vitro E.coli expression system
CSB-YP007928RB1 CSB-EP007928RB1 CSB-BP007928RB1 CSB-MP007928RB1 CSB-EP007928RB1-B	Recombinant Rabbit Tissue factor (F3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

F3 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-CF007928MO	Recombinant Mouse Tissue factor (F3)	in vitro E.coli expression system
CSB-YP007928MO1 CSB-EP007928MO1 CSB-BP007928MO1 CSB-EP007928MO1-B	Recombinant Mouse Tissue factor (F3), partial	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli