The actin cytoskeleton is a dynamic network composed of actin polymers and associated actin binding proteins. The actin cytoskeleton was first isolated as a component of the actomyosin complex in muscle cells and was later identified as a component of all eukaryotic cells. It is highly conserved throughout evolution.
The actin cytoskeleton is a primary determinant of cell shape and motility. Combining with the other parts of the cytoskeleton including intermediate filaments and microtubules, the actin cytoskeleton is mainly responsible for mediating various important cellular processes such as cell structural support, axonal growth, cell migration, organelle transport and phagocytosis.
For the actin cytoskeleton to perform these functions, its organization requires tight regulation and many of the associated actin binding proteins are therefore probable targets of the cellular signaling pathways that modulate the assembly of actin.
Signaling to the cytoskeleton through G protein-coupled receptors (GPCRs), integrins, receptor tyrosine kinases (RTKs), and numerous other specialized receptors, such as the semaphorin 1a receptor PlexinA, can lead to diverse effects on cell activity, including changes in cell shape, migration, proliferation, and survival.
Intracellular regulation of the cell’s response to external cues occurs through a large number of signaling cascades that include the Rho family of small GTPases (Rho, Rac, and Cdc42) and their activators, guanine nucleotide exchange factors (GEFs), their downstream protein kinase effectors, including Rho-kinase/ROCK and p21 activated kinase (PAK), as well as through direct binding of the GTPases to several actin regulatory proteins, such as mDia, WAVE, and WASP.
These cascades converge on proteins that directly regulate the behavior and organization of the actin cytoskeleton, including actin interacting regulatory proteins such as Arp2/3 complex, Ena/VASP, profilin, and gelsolin. Signaling through different pathways can lead to the formation of distinct actin-dependent structures whose coordinated assembly/disassembly is important for directed cell migration and other cellular behaviors.
|RHOA||RHOA Antibody||RHOA Protein||RHOA cDNA||RHOA ELISA Kit|
|ROCK1||ROCK1 Antibody||ROCK1 Protein||ROCK1 cDNA||ROCK1 ELISA Kit|
|ROCK2||ROCK2 Antibody||ROCK2 Protein||ROCK2 cDNA||ROCK2 ELISA Kit|
|RRAS||RRAS Antibody||RRAS Protein||RRAS cDNA||RRAS ELISA Kit|
|RRAS2||RRAS2 Antibody||RRAS2 Protein||RRAS2 cDNA||RRAS2 ELISA Kit|
|SCIN||SCIN Antibody||SCIN Protein||SCIN cDNA||SCIN ELISA Kit|
|SLC9A1||SLC9A1 Antibody||SLC9A1 Protein||SLC9A1 cDNA||SLC9A1 ELISA Kit|
|SOS1||SOS1 Antibody||SOS1 Protein||SOS1 cDNA||SOS1 ELISA Kit|
|SOS2||SOS2 Antibody||SOS2 Protein||SOS2 cDNA||SOS2 ELISA Kit|
|SPATA13||SPATA13 Antibody||SPATA13 Protein||SPATA13 cDNA||SPATA13 ELISA Kit|
|SRC||SRC Antibody||SRC Protein||SRC cDNA||SRC ELISA Kit|
|SSH1||SSH1 Antibody||SSH1 Protein||SSH1 cDNA||SSH1 ELISA Kit|
|SSH2||SSH2 Antibody||SSH2 Protein||SSH2 cDNA||SSH2 ELISA Kit|
|SSH3||SSH3 Antibody||SSH3 Protein||SSH3 cDNA||SSH3 ELISA Kit|
|TIAM1||TIAM1 Antibody||TIAM1 Protein||TIAM1 cDNA||TIAM1 ELISA Kit|
|TMSB4X||TMSB4X Antibody||TMSB4X Protein||TMSB4X cDNA||TMSB4X ELISA Kit|
|TMSB4Y||TMSB4Y Antibody||TMSB4Y Protein||TMSB4Y cDNA||TMSB4Y ELISA Kit|
|VAV1||VAV1 Antibody||VAV1 Protein||VAV1 cDNA||VAV1 ELISA Kit|
|VAV2||VAV2 Antibody||VAV2 Protein||VAV2 cDNA||VAV2 ELISA Kit|
|VAV3||VAV3 Antibody||VAV3 Protein||VAV3 cDNA||VAV3 ELISA Kit|