BCL6

B-cell lymphoma 6 protein is a protein in humans that is encoded by BCL6 gene. Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155.

BCL6 Antibodies

BCL6 Antibodies for Homo sapiens (Human)

BCL6 Proteins

BCL6 Proteins for Mus musculus (Mouse)

BCL6 Proteins for Homo sapiens (Human)

BCL6 Proteins for Gallus gallus (Chicken)

BCL6 ELISA Kit

BCL6 ELISA Kit for Homo sapiens (Human)

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