CLEC9A

CLEC9A encodes C-type lectin domain family 9 member A, commonly known as DNGR-1. Expressed primarily on conventional dendritic cells (cDC1s), it acts as a pattern recognition receptor binding to exposed F-actin from necrotic cells. This interaction activates Syk-CARD9 signaling, driving cross-presentation of dead cell-derived antigens to CD8+ T cells—critical for adaptive immunity against pathogens and tumors.
Dysregulation of CLEC9A links to autoimmune disorders like systemic lupus erythematosus, where excessive cross-presentation may trigger self-reactive T cells. In oncology, targeting CLEC9A to enhance cDC1 function is promising; preclinical studies use agonistic antibodies to boost anti-tumor immunity, with early-phase clinical trials underway to validate efficacy.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Anti-CLEC9A recombinant antibody (CSB-RA740922MA1HU) at 2 μg/ml can bind Human CLEC9A protein. The EC₅₀ is 2.915-3.520 ng/mL.

CLEC9A Recombinant Monoclonal Antibody (CSB-RA740922MA1HU)

Validated Data

The Binding Activity of Human CLEC9A with Anti-CLEC9A recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Anti-CLEC9A recombinant antibody at 2 μg/mL can bind Human CLEC9A protein (CSB-MP740922HU-B). The EC₅₀ is 2.915-3.520 ng/mL.

Human C-type lectin domain family 9 member A(CLEC9A) ELISA kit (CSB-EL005542HU)

Validated Data

Code: CSB-EL005542HU

Size: 96T,5×96T,10×96T

Sensitivity: 0.078 ng/mL

Detection Range: 0.312 ng/mL-20 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

The following CLEC9A reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

CLEC9A Antibodies

CLEC9A Proteins

CLEC9A ELISA Kits

CLEC9A Antibodies

CLEC9A Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA740922HA01HU	CLEC9A Antibody	Human, Mouse	ELISA, WB, IF
CSB-PA740922HB01HU	CLEC9A Antibody, HRP conjugated	Human	ELISA
CSB-PA740922HC01HU	CLEC9A Antibody, FITC conjugated	Human
CSB-PA740922HD01HU	CLEC9A Antibody, Biotin conjugated	Human	ELISA
CSB-RA740922MA1HU	CLEC9A Recombinant Monoclonal Antibody	Human	ELISA

CLEC9A Proteins

CLEC9A Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-EP740922HU CSB-BP740922HU CSB-MP740922HU CSB-EP740922HU-B	Recombinant Human C-type lectin domain family 9 member A (CLEC9A), partial	E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-MP740922HU-B	Recombinant Human C-type lectin domain family 9 member A (CLEC9A), partial, Biotinylated (Active)	Mammalian cell
CSB-YP740922HU	Recombinant Human C-type lectin domain family 9 member A (CLEC9A), partial	Yeast

CLEC9A Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP806896MO CSB-EP806896MO CSB-BP806896MO CSB-MP806896MO CSB-EP806896MO-B	Recombinant Mouse C-type lectin domain family 9 member A (Clec9a), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CLEC9A Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-CF005542RA	Recombinant Rat C-type lectin domain family 9 member A (Clec9a)	in vitro E.coli expression system
CSB-YP005542RA1 CSB-EP005542RA1 CSB-BP005542RA1 CSB-MP005542RA1 CSB-EP005542RA1-B	Recombinant Rat C-type lectin domain family 9 member A (Clec9a), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CLEC9A ELISA Kit

CLEC9A ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-EL005542HU	Human C-type lectin domain family 9 member A(CLEC9A) ELISA kit	serum, plasma, tissue homogenates, cell lysates	0.078 ng/mL

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CLEC9A

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