CSNK1A1

CSNK1A1 encodes casein kinase 1 alpha 1 (CK1α), a serine/threonine kinase that phosphorylates substrates like β-catenin, PER proteins, and p53. It modulates Wnt/β-catenin signaling by targeting β-catenin for degradation, regulates circadian rhythm via PER phosphorylation, and influences cell cycle progression.
Dysregulation of CSNK1A1 is linked to acute myeloid leukemia (AML) and colorectal cancer, where its overactivity drives tumor growth through Wnt pathway activation. Small-molecule inhibitors such as PF-670462 have demonstrated preclinical efficacy in AML models, and early-phase clinical trials are investigating their use for hematological malignancies.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP006065HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) CSNK1A1.

CSNK1A1 Antibody (CSB-PA006065LA01HU)

Validated Data

Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA006065LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA006065LA01HU at dilution of 1:100

The following CSNK1A1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

CSNK1A1 Antibodies

CSNK1A1 Proteins

CSNK1A1 Antibodies

CSNK1A1 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA006065LA01HU	CSNK1A1 Antibody	Human	ELISA, IHC
CSB-PA833830	CSNK1A1 Antibody	Human,Mouse,Rat	ELISA,WB,IHC,IF
CSB-PA001224	CSNK1A1 Antibody	Human,Mouse,Rat	WB, IHC, IF, ELISA
CSB-PA001225	CSNK1A1 Antibody	Human,Mouse,Rat	WB, IHC, IF, ELISA
CSB-PA007354	Phospho-CSNK1A1 (Y321) Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA276669	CSNK1A1 Antibody	Human,Mouse	ELISA,WB,IHC

CSNK1A1 Proteins

CSNK1A1 Proteins for Ovis aries (Sheep)

Code	Product Name	Source
CSB-YP006065SH CSB-EP006065SH CSB-BP006065SH CSB-MP006065SH CSB-EP006065SH-B	Recombinant Sheep Casein kinase I isoform alpha (CSNK1A1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CSNK1A1 Proteins for Gallus gallus (Chicken)

Code	Product Name	Source
CSB-YP006065CH CSB-EP006065CH CSB-BP006065CH CSB-MP006065CH CSB-EP006065CH-B	Recombinant Chicken Casein kinase I isoform alpha (CSNK1A1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CSNK1A1 Proteins for Oryctolagus cuniculus (Rabbit)

Code	Product Name	Source
CSB-YP006065RB CSB-EP006065RB CSB-BP006065RB CSB-MP006065RB CSB-EP006065RB-B	Recombinant Rabbit Casein kinase I isoform alpha (CSNK1A1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CSNK1A1 Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP006065BO CSB-EP006065BO CSB-BP006065BO CSB-MP006065BO CSB-EP006065BO-B	Recombinant Bovine Casein kinase I isoform alpha (CSNK1A1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CSNK1A1 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP006065HU CSB-BP006065HU CSB-MP006065HU CSB-EP006065HU-B	Recombinant Human Casein kinase I isoform alpha (CSNK1A1)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP006065HU	Recombinant Human Casein kinase I isoform alpha (CSNK1A1)	E.coli

CSNK1A1 Proteins for Sus scrofa (Pig)

Code	Product Name	Source
CSB-YP006065PI CSB-EP006065PI CSB-BP006065PI CSB-MP006065PI CSB-EP006065PI-B	Recombinant Pig Casein kinase I isoform alpha (CSNK1A1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CSNK1A1 Proteins for Xenopus laevis (African clawed frog)

Code	Product Name	Source
CSB-YP006065XBE CSB-EP006065XBE CSB-BP006065XBE CSB-MP006065XBE CSB-EP006065XBE-B	Recombinant Xenopus laevis Casein kinase I isoform alpha (csnk1a1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CSNK1A1 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP006065RA CSB-EP006065RA CSB-BP006065RA CSB-MP006065RA CSB-EP006065RA-B	Recombinant Rat Casein kinase I isoform alpha (Csnk1a1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CSNK1A1 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP805291MO CSB-EP805291MO CSB-BP805291MO CSB-MP805291MO CSB-EP805291MO-B	Recombinant Mouse Casein kinase I isoform alpha (Csnk1a1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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CSNK1A1

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