The provided gene symbol "EPX" corresponds to Eosinophil Peroxidase, a heme-containing enzyme primarily expressed in eosinophils. It catalyzes the production of hypohalous acids, contributing to microbicidal and cytotoxic activities during innate immune responses. EPX is involved in the respiratory burst pathway, where it acts downstream of NADPH oxidase to generate reactive oxygen species.
Dysregulated EPX expression is associated with eosinophilic disorders such as asthma, allergic rhinitis, and hypereosinophilic syndrome. Its role in tissue damage during chronic inflammation makes it a potential therapeutic target, though specific drug development targeting EPX remains in preclinical stages, focusing on small-molecule inhibitors to modulate eosinophil-mediated pathology.
Recombinant Human Eosinophil peroxidase (EPX) (CSB-EP007756HU)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
EPX Antibody (CSB-PA007756LA01HU)
Validated Data
IHC image of CSB-PA007756LA01HU diluted at 1:100 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody
IHC image of CSB-PA007756LA01HU diluted at 1:100 and staining in paraffin-embedded human ovarian cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody
IHC image of CSB-PA007756LA01HU diluted at 1:100 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody
Human Eosinophil peroxidase(EPX) ELISA kit (CSB-EL007756HU)
Validated Data
Code: CSB-EL007756HU
Size: 96T,5×96T,10×96T
Sensitivity: 0.78 ng/mL
Detection Range: 3.12 ng/mL-200 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
The following EPX reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
EPX Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA007756LA01HU | EPX Antibody | Human | ELISA, IHC |
| CSB-PA007756LB01HU | EPX Antibody, HRP conjugated | Human | ELISA |
| CSB-PA007756LC01HU | EPX Antibody, FITC conjugated | Human | |
| CSB-PA007756LD01HU | EPX Antibody, Biotin conjugated | Human | ELISA |
EPX Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-BP007756HU CSB-MP007756HU CSB-EP007756HU-B |
Recombinant Human Eosinophil peroxidase (EPX) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP007756HU | Recombinant Human Eosinophil peroxidase (EPX) | E.coli |
| CSB-YP007756HU | Recombinant Human Eosinophil peroxidase (EPX) | Yeast |
| CSB-EP007756HUc7 | Recombinant Human Eosinophil peroxidase (EPX) | E.coli |
EPX ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-EL007756HU | Human Eosinophil peroxidase(EPX) ELISA kit | serum, plasma, cell culture supernates, tissue homogenates | 0.78 ng/mL |