GBA1

GBA1, or lysosomal acid β-glucocerebrosidase, is an enzyme widely distributed in human cells, with particularly high expression in neurons and macrophages. Its structure comprises multiple functional domains that work together to catalyze the hydrolysis of glucocerebroside, thereby maintaining the balance of glucose and cerebroside inside and outside the cell. GBA1 not only plays a crucial role in lipid metabolism, affecting the structure and function of cell membranes as well as intracellular signal transduction, but is also intimately linked to the normal function of the nervous system. Abnormalities in its function may lead to neurodegenerative diseases such as Gaucher disease. Furthermore, GBA1 is closely associated with multiple intracellular signaling pathways, including the phosphatidylinositol-3-kinase (PI3K) signaling pathway, autophagy processes, and inflammatory responses, jointly regulating cellular processes such as growth, proliferation, apoptosis, and immune responses.

Popular Product:

Recombinant Human Lysosomal acid glucosylceramidase (GBA1)

Validated Data

SDS

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

LCMS

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP009289HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) GBA.

LCMS

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP009289HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) GBA.