GHSR

GHS-R, the growth hormone releasing hormone receptor, also identified as growth hormone receptor type 1, is predominantly expressed in tissues such as the brain, gastrointestinal tract, and pancreas. It activates upon binding with GHRH, initiating a cascade that enhances adenylate cyclase activity, elevates cAMP levels, and triggers protein kinase A (PKA) activation, culminating in the release of growth hormone (GH). GHS-R's role extends to the regulation of growth and development, energy metabolism, appetite control, and stress response, with its dysregulation implicated in conditions like obesity and growth hormone deficiency. It stands as a significant target in endocrinology and metabolic disease research, with targeted drug development showing promise for related disease treatments.