GPRC5B

GPRC5B encodes the G protein-coupled receptor class C group 5 member B, a orphan receptor predominantly expressed in metabolic tissues. It lacks established endogenous ligands but interacts with intracellular signaling cascades, potentially modulating Gαi/o-mediated pathways. Emerging studies link GPRC5B to energy homeostasis, with knockout models showing altered adiposity and glucose metabolism.
Dysregulation of GPRC5B is associated with metabolic disorders, including obesity and type 2 diabetes. Preclinical research investigates its role as a therapeutic target, focusing on small-molecule modulators to regulate metabolic signaling. However, clinical development remains preliminary, with no approved drugs targeting this receptor to date.