GPX4

GPX4, recognized as glutathione peroxidase 4, is a vital enzyme and the fourth member of the selenium-containing GPX family, found across various organisms. This enzyme neutralizes the harmful effects of lipid peroxides through its catalytic activity, helping to maintain the integrity of cell membranes and protecting against ferroptosis, a form of programmed cell death. Biologically, GPX4 serves as a key regulator in preventing ferroptosis, which is essential for cell survival and homeostasis. Additionally, GPX4 expression is significantly elevated in many tumor tissues, indicating its potential role in cancer development. This makes GPX4 a promising target for modulating cancer immunotherapy and highlights its therapeutic potential in treating various diseases.