HRH3

HRH3, histamine receptor H3, alias histamine H3 receptor. It is a member of the G protein-coupled receptor (GPCR) family, and is mainly expressed on histaminergic neurons in the central nervous system, but also plays a role in peripheral tissues such as immune cells, etc. The mechanism of action of HRH3 involves the regulation of the synthesis and release of neurotransmitters, acting as an autoreceptor to inhibit the synthesis and secretion of histamine presynaptically, and as a heterodimeric receptor to regulate the activity of other neurotransmitters postsynaptically. Activation of HRH3 can affect a variety of physiological processes, including the sleep-wake cycle, appetite, cognitive function, and cerebral ischemia, etc.

HRH3 has a wide range of biological significance, and it is not only involved in the regulation of the central nervous system, but is also associated with the development of a variety of diseases. For example, in the liver, the expression level of HRH3 is associated with the development of hepatocellular carcinoma. In addition, HRH3 has been implicated in autoimmune diseases such as multiple sclerosis, which integrates peripheral inflammatory signaling in neurogenic control.Abnormalities in HRH3 function have been associated with negative symptoms and cognitive functioning in psychiatric disorders such as schizophrenia, and thus the development of HRH3 antagonists has provided new strategies for the treatment of these disorders.