HTR1A

HTR1A, the 5-hydroxytryptamine 1A receptor, alias ADRB2RL1, ADRBRL1, 5-hydroxytryptamine receptor 1A, 5-HT-1A, 5-HT1A, G-21, Serotonin receptor 1A. it is a G-protein-coupled receptor widely distributed in the brain receiving serotonergic signals from the It is a G-protein coupled receptor widely distributed in the region of the brain that receives serotonergic signals from the nucleus accumbens, and is a key mediator of serotonin signaling in the central nervous system.HTR1A is encoded by the HTR1A gene, and its mechanism of action is mainly to activate the G-protein by binding to ligands such as 5-hydroxytryptophan (5-HT) and thereby regulating the activities of downstream effectors, such as adenylate cyclase, and affecting intracellular signaling.

The significance of HTR1A in biology is HTR1A has a wide range of biological significance and is involved in the regulation of a variety of physiological functions, including mood, sleep, pain perception, cognitive function, and regulation of the autonomic nervous system, etc. The activity of HTR1A is also closely associated with the development of a variety of diseases, such as depression, anxiety disorders, migraines, Parkinson's disease, irritable bowel syndrome, epilepsy, post-partum depression, anxiety disorders, sleep disorders, congenital central hypoventilation syndrome, eating disorders, alcohol dependence, endogenous depression, and other disorders. , alcohol dependence, endogenous depression, anorexia nervosa, bulimia nervosa, pathological gambling, Machado-Joseph disease (an inherited movement disorder), chronic pain, anhedonia, and migraine without aura. Thus, HTR1A is an important target in psychopharmacological research and treatment of related disorders .