HTR4

The 5-hydroxytryptamine receptor 4 (HTR4), commonly known as 5-HT4R, is a G-protein coupled receptor (GPCR) that signals via Gs proteins. Upon activation by serotonin, it stimulates adenylate cyclase to increase intracellular cyclic adenosine monophosphate (cAMP) levels, activating the cAMP-dependent protein kinase A (PKA) pathway. This mechanism regulates neurotransmitter release (e.g., acetylcholine in the gastrointestinal tract) and neuronal excitability.
HTR4 dysregulation links to gastrointestinal disorders like irritable bowel syndrome with constipation (IBS-C) due to its role in promoting intestinal motility. Neurologically, it modulates cognitive function, with implications for Alzheimer’s disease. Approved drugs include prucalopride, an HTR4 agonist for IBS-C, while investigational agents target cognitive impairment by enhancing cholinergic signaling.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

HTR4 Antibody (CSB-PA010895LA01HU)

Validated Data

Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA010895LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA010895LA01HU at dilution of 1:100

Immunofluorescence staining of MCF-7 cells with CSB-PA010895LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

The following HTR4 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

HTR4 Antibodies

HTR4 Proteins

HTR4 Antibodies

HTR4 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA086567	HTR4 Antibody	Human,Mouse,Rat	ELISA,WB,IF
CSB-PA004151	HTR4 Antibody	Human,Mouse,Rat	WB, IHC, IF, ELISA
CSB-PA009360	HTR4 Antibody	Human,Rat	WB, IF, ELISA
CSB-PA790181	HTR4 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA010895LA01HU	HTR4 Antibody	Human	ELISA, IHC, IF
CSB-PA010895LB01HU	HTR4 Antibody, HRP conjugated	Human	ELISA
CSB-PA010895LC01HU	HTR4 Antibody, FITC conjugated	Human
CSB-PA010895LD01HU	HTR4 Antibody, Biotin conjugated	Human	ELISA

HTR4 Antibodies for Arabidopsis thaliana (Mouse-ear cress)

Code	Product Name	Species Reactivity	Application
CSB-PA010109XA01DOA	HTR4 Antibody	Arabidopsis thaliana	ELISA, WB (ensure identification of antigen)

HTR4 Proteins

HTR4 Proteins for Arabidopsis thaliana (Mouse-ear cress)

Code	Product Name	Source
CSB-YP010109DOA CSB-EP010109DOA CSB-BP010109DOA CSB-MP010109DOA CSB-EP010109DOA-B	Recombinant Arabidopsis thaliana Histone H3.3 (HTR4)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

HTR4 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-CF622677HU	Recombinant Human 5-hydroxytryptamine receptor 4 (HTR4)	in vitro E.coli expression system
CSB-YP622677HU1 CSB-EP622677HU1 CSB-BP622677HU1 CSB-MP622677HU1 CSB-EP622677HU1-B	Recombinant Human 5-hydroxytryptamine receptor 4 (HTR4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF622677HU2	Recombinant Human 5-hydroxytryptamine receptor 4 (HTR4), partial	in vitro E.coli expression system

HTR4 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-CF010895MO	Recombinant Mouse 5-hydroxytryptamine receptor 4 (Htr4)	in vitro E.coli expression system
CSB-YP010895MO1 CSB-EP010895MO1 CSB-BP010895MO1 CSB-MP010895MO1 CSB-EP010895MO1-B	Recombinant Mouse 5-hydroxytryptamine receptor 4 (Htr4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

HTR4 Proteins for Cavia porcellus (Guinea pig)

Code	Product Name	Source
CSB-CF010895GU	Recombinant Guinea pig 5-hydroxytryptamine receptor 4 (HTR4)	in vitro E.coli expression system
CSB-YP010895GU1 CSB-EP010895GU1 CSB-BP010895GU1 CSB-MP010895GU1 CSB-EP010895GU1-B	Recombinant Guinea pig 5-hydroxytryptamine receptor 4 (HTR4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

HTR4 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-CF737092RA	Recombinant Rat 5-hydroxytryptamine receptor 4 (Htr4)	in vitro E.coli expression system
CSB-YP737092RA1 CSB-EP737092RA1 CSB-BP737092RA1 CSB-MP737092RA1 CSB-EP737092RA1-B	Recombinant Rat 5-hydroxytryptamine receptor 4 (Htr4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

HTR4 Proteins for Sus scrofa (Pig)

Code	Product Name	Source
CSB-YP642742PI CSB-EP642742PI CSB-BP642742PI CSB-MP642742PI CSB-EP642742PI-B	Recombinant Pig 5-hydroxytryptamine receptor 4 (HTR4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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HTR4

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