IFNB1

Interferon beta (IFN-β), encoded by the IFNB1 gene, is a cytokine belonging to the type I interferon family. Also termed Fibroblast Interferon, it binds to the heterodimeric IFN-α/β receptor (IFNAR), activating JAK-STAT signaling pathways. This triggers transcription of interferon-stimulated genes (ISGs), mediating antiviral defense, immune modulation, and antiproliferative effects. Key pathways influenced include Toll-like receptor (TLR) cascades and RIG-I-like receptor signaling, with cross-talk in autoimmune regulation. IFN-β is clinically pivotal in multiple sclerosis (MS), where it reduces relapse rates by suppressing T-cell activation and blood-brain barrier disruption. Recombinant IFN-β1a (Avonex) and IFN-β1b (Betaseron) remain first-line therapies, though newer agents like monoclonal antibodies now complement treatment regimens. Recent trials explore pegylated formulations and combination therapies with sphingosine-1-phosphate receptor modulators to enhance efficacy and tolerability.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

IFNB1 (dazukibart) Recombinant Monoclonal Antibody (CSB-RA011048MA1HU)

Validated Data

IHC image of CSB-RA011048MA1HU diluted at 1:300 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Human IgG labeled by HRP and visualized using 0.05% DAB.

The following IFNB1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

IFNB1 Antibodies

IFNB1 Proteins

IFNB1 ELISA Kits

IFNB1 Antibodies

IFNB1 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA06515A0Rb	IFNB1 Antibody	Human	ELISA, IHC
CSB-PA06515B0Rb	IFNB1 Antibody, HRP conjugated	Human	ELISA
CSB-PA06515D0Rb	IFNB1 Antibody, Biotin conjugated	Human	ELISA
CSB-RA011048MA1HU	IFNB1 (dazukibart) Recombinant Monoclonal Antibody	Human	ELISA, IHC

IFNB1 Antibodies for Equus caballus (Horse)

Code	Product Name	Species Reactivity	Application
CSB-PA011048XA01HO	IFNB1 Antibody	Equus caballus (Horse)	ELISA, WB (ensure identification of antigen)

IFNB1 Proteins

IFNB1 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-EP011048RA CSB-BP011048RA CSB-MP011048RA CSB-EP011048RA-B	Recombinant Rat Interferon beta (Ifnb1)	E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IFNB1 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP011048HU CSB-BP011048HU CSB-EP011048HU-B	Recombinant Human Interferon beta (IFNB1)	Yeast Baculovirus In Vivo Biotinylation in E.coli
CSB-AP002791HU	Recombinant Human Interferon beta protein (IFNB1) (Active)	E.coli
CSB-EP011048HU	Recombinant Human Interferon beta protein (IFNB1)	E.coli
CSB-EP011048HUe1	Recombinant Human Interferon beta (IFNB1)	E.coli

IFNB1 Proteins for Equus caballus (Horse)

Code	Product Name	Source
CSB-YP011048HO CSB-EP011048HO CSB-BP011048HO CSB-MP011048HO CSB-EP011048HO-B	Recombinant Horse Interferon beta (IFNB1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IFNB1 Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP011048BO CSB-EP011048BO CSB-BP011048BO CSB-MP011048BO CSB-EP011048BO-B	Recombinant Bovine Interferon beta-1 (IFNB1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IFNB1 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP011048MO CSB-EP011048MO CSB-BP011048MO CSB-EP011048MO-B	Recombinant Mouse Interferon beta (Ifnb1)	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli

IFNB1 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Code	Product Name	Source
CSB-YP011048MOV CSB-EP011048MOV CSB-BP011048MOV CSB-EP011048MOV-B	Recombinant Macaca fascicularis Interferon beta (IFNB1)	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli

IFNB1 Proteins for Tachyglossus aculeatus aculeatus (Southeast Australian short-beaked echidna)

Code	Product Name	Source
CSB-YP747707TKU CSB-EP747707TKU CSB-BP747707TKU CSB-MP747707TKU CSB-EP747707TKU-B	Recombinant Tachyglossus aculeatus aculeatus Interferon beta (IFNB1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IFNB1 Proteins for Felis catus (Cat) (Felis silvestris catus)

Code	Product Name	Source
CSB-YP863088CA CSB-EP863088CA CSB-BP863088CA CSB-MP863088CA CSB-EP863088CA-B	Recombinant Cat Interferon beta (IFNB1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IFNB1 ELISA Kit

IFNB1 ELISA Kit for Bos taurus (Bovine)

Code	Product Name	Sample Types	Sensitivity
CSB-E13699B	Bovine Interferon β,IFN-β/IFNB ELISA Kit

IFNB1 ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-E09889h	Human Interferon β,IFN-β/IFNB ELISA Kit	serum, urine, cell culture supernates, tissue homogenates, cerebrospinal fluid (CSF)	7.8 pg/mL

IFNB1 ELISA Kit for Mus musculus (Mouse)

Code	Product Name	Sample Types	Sensitivity
CSB-E04945m	Mouse Interferon β,IFN-β/IFNB ELISA Kit	serum, plasma, cell culture supernates, tissue homogenates, cell lysates	3.9 pg/mL

IFNB1 ELISA Kit for Rattus norvegicus (Rat)

Code	Product Name	Sample Types	Sensitivity
CSB-E04845r	Rat Interferon β,IFN-β/IFNB ELISA Kit	serum, plasma, tissue homogenates	3.9 pg/mL

IFNB1 ELISA Kit for Monkey

Code	Product Name	Sample Types	Sensitivity
CSB-E17829Mk	Monkey Interferon β(IFN-β)ELISA Kit	serum, plasma	7.8 pg/mL

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IFNB1

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