Interleukin-20 (IL-20), also termed IL-20A or cytokine ZCYTO10, is a member of the IL-10 cytokine family. It signals through two heterodimeric receptor complexes: IL-20R1/IL-20R2 and IL-22R1/IL-20R2, activating JAK-STAT pathways, particularly STAT3 phosphorylation. This cytokine regulates epithelial cell functions, keratinocyte proliferation, and osteoclastogenesis, with roles in tissue remodeling and inflammatory responses. Key pathways include JAK-STAT, MAPK, and PI3K/Akt cascades, intersecting with immune regulation and cellular differentiation processes. Dysregulation of IL-20 is implicated in psoriasis, rheumatoid arthritis, and atherosclerosis, driven by its pro-inflammatory effects on endothelial cells and synoviocytes.
Elevated IL-20 expression correlates with psoriasis pathogenesis, where it promotes epidermal hyperplasia and immune cell infiltration. It also contributes to bone resorption in osteoporosis via RANKL-independent osteoclast activation. Therapeutic strategies targeting IL-20 or its receptors include monoclonal antibodies like fletikumab (Phase II) and bispecific agents such as bimekizumab (approved for psoriasis/psoriatic arthritis). Small-molecule inhibitors blocking IL-20R dimerization are under preclinical evaluation. Recent studies highlight its potential role in cancer-associated cachexia and diabetic nephropathy, expanding its clinical relevance beyond classical inflammatory disorders.
IL20 Antibody (CSB-PA873699ESR2HU)
Validated Data
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA873699ESR2HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA873699ESR2HU at dilution of 1:100
The following IL20 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
IL20 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA020218 | IL20 Antibody | Human,Mouse | WB, ELISA |
CSB-PA270025 | IL20 Antibody | Human | ELISA,IHC |
CSB-PA130699 | IL20 Antibody | Human | ELISA,IHC |
CSB-PA873699ESR2HU | IL20 Antibody | Human | ELISA, IHC |
IL20 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP872875MO CSB-EP872875MO CSB-BP872875MO CSB-MP872875MO CSB-EP872875MO-B |
Recombinant Mouse Interleukin-20 (Il20) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL20 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP873699HU CSB-EP873699HU CSB-BP873699HU CSB-MP873699HU CSB-EP873699HU-B |
Recombinant Human Interleukin-20 (IL20) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-AP001871HU | Recombinant Human Interleukin-20 protein (IL20) (Active) | E.coli |
IL20 ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E15015h | Human Interleukin 20(IL-20)ELISA Kit | serum, plasma, tissue homogenates | 0.078 ng/ml |
IL20 ELISA Kit for Mus musculus (Mouse)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL011630MO | Mouse Interleukin-20(IL20) ELISA kit | serum, plasma, tissue homogenates | 7.8 pg/ml |