IL4RA

IL4RA, interleukin 4 receptor alpha chain, which is a cell surface receptor, is mainly derived from activated CD4+ T cells, but also produced by a variety of cells such as NKT cells, macrophages, eosinophils, etc. The mechanism of action of IL4RA is to bind to IL-4 and IL-13 and exert its biological functions through activation of the JAK-STAT signalling pathway, in particular through STAT6 phosphorylation and activation, to exert its biological function.IL4RA is important for the regulation of immune response, promotion of Th2 cell differentiation, B cell antibody class switching, and inhibition of inflammatory response. Aberrant expression of IL4RA is closely related to the development of allergic and inflammatory diseases.