ITGB3

ITGB3, the integrin β3 subunit, is a crucial component of cell adhesion molecules located on human chromosome 17. This gene encodes a protein that pairs with the α subunit to form integrins, which are essential for cell adhesion, migration, differentiation, and signal transduction. ITGB3 plays a key role in mediating the interaction between cells and the extracellular matrix, particularly in platelets where it combines with the αIIb chain to form the αIIbβ3 integrin, a vital participant in the blood coagulation process. Abnormal ITGB3 expression is linked to various diseases, including thrombotic disorders and tumor metastasis, making it a potential target and biomarker for medical research and treatment.