MOB1A

MOB kinase activator 1A is a protein in humans that is encoded by MOB1A gene. Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38.

MOB1A Antibodies

MOB1A Antibodies for Homo sapiens (Human)

MOB1A Antibodies for Human

MOB1A Proteins

MOB1A Proteins for Rattus norvegicus (Rat)

MOB1A Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

MOB1A Proteins for Mus musculus (Mouse)

MOB1A Proteins for Homo sapiens (Human)

Newsletters

Get all the latest information on Events, Sales and Offers. Sign up for newsletter today.

Copyright © 2007-2018 www.cusabio.com CUSABIO TECHNOLOGY LLC All Rights Reserved.

Wait!

Join the 25,000 subscribers to get research hotpots, technical tips, latest information on events, sales and offers.

Sign up now!

We don't deal in spam.