NTN1

NTN1, also known as Netrin-1, is a protein composed of an α-helical structure and encoded by the NTN1 gene. This protein plays a crucial role in the development of neurons. NTN1 guides the growth of neuronal axons and the formation of synapses by recognizing and binding to its receptors. This binding often depends on the presence of Ca2+ ions, which activates endogenous signaling pathways through the receptor, ultimately affecting neuronal development and function. Additionally, Netrin-1 can inhibit the apoptosis (cell death) of tumor cells, promote the formation of new blood vessels, and regulate fibroblasts. Netrin-1 is also involved in the epithelial-mesenchymal transition (EMT) process, which is closely related to tumorigenesis, progression, metastasis, and drug resistance. Blocking Netrin-1 can inhibit the EMT process, thereby exerting a significant impact on tumor development.