P2RY6

P2RY6, also known as P2Y6, is a pyrimidinergic receptor that plays a crucial role in cellular signaling. This protein, also referred to as P2Y purinoceptor 6, is activated by extracellular nucleotides and is involved in various physiological processes, including inflammation and immune response. P2RY6 is a member of the P2Y receptor family, which is known for its involvement in regulating cellular responses to nucleotides. The signaling pathway of P2RY6 is complex and can lead to diverse outcomes, including the promotion of inflammation and immune evasion in certain cancers, such as lung adenocarcinoma (LUAD). Research suggests that P2RY6 may be a potential therapeutic target for cancer immunotherapy, and its expression levels have been associated with patient prognosis and disease progression. Current drug development efforts are focused on understanding the role of P2RY6 in the tumor microenvironment and exploring novel strategies for targeting this receptor in clinical settings.