PPARA

PPARA, peroxisome proliferator-activated receptor alpha, aliases include PPARα, NR1C1.PPARA is a nuclear receptor, a member of the PPAR family, encoded by its own gene in human cells.PPARA is expressed in a variety of tissues, including liver, heart, skeletal muscle, kidney, and brown adipose tissue. PPARA is expressed in various tissues such as liver, heart, skeletal muscle, kidney and brown adipose tissue, etc. Its mechanism of action is to activate the receptor by binding to specific ligands, such as fatty acids and their derivatives, and to form heterodimers that bind to PPAR response elements (PPREs) on DNA to regulate the expression of downstream genes, thus participating in the processes of lipid metabolism, energy homeostasis, and cell proliferation. PPARA plays a key role in the regulation of fatty acid oxidation, cholesterol metabolism, inflammatory response, cell differentiation and tumorigenesis, etc.

Activation of PPARA promotes mitochondrial fatty acid oxidation, improves the efficiency of energy metabolism, reduces plasma cholesterol and triglyceride levels, and fights against atherosclerosis. In addition, PPARA is involved in the regulation of hepatic detoxification and influences the metabolism of drugs and toxins.Agonists of PPARA, such as fibrates, are widely used in the treatment of hyperlipidemia and related cardiovascular diseases. Therefore, PPARA is an important target in the research and treatment of metabolic and cardiovascular diseases.