PTK7

PTK7, or protein tyrosine kinase 7, is a non-receptor protein tyrosine kinase encoded by the PTK7 gene and plays a role in development and immune response. It interacts with various proteins and is involved in cell polarity, migration, and proliferation, particularly in embryonic development and tumor cell invasion. PTK7 regulates intracellular signaling pathways like Wnt/PCP and classical Wnt pathways, affecting cell polarity, movement, migration, and invasion. Its dysfunction is associated with tumor occurrence and development.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human PTK7 at 2 μg/ml can bind Anti-PTK7 recombinant antibody (CSB-RA622651MA1HU). The EC₅₀ is 0.3675 - 0.65842 ng/mL.

The purity of PTK7 was greater than 95% as determined by SEC-HPLC

PTK7 Antibody (CSB-PA018996LA01HU)

Validated Data

IHC image of CSB-PA018996LA01HU diluted at 1:100 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Human Inactive tyrosine-protein kinase 7(PTK7) ELISA kit (CSB-EL018996HU)

Validated Data

Code: CSB-EL018996HU

Size: 96T,5×96T,10×96T

Sensitivity: 3.125 pg/mL

Detection Range: 12.5 pg/mL-800 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

The following PTK7 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

PTK7 Antibodies

PTK7 Proteins

PTK7 ELISA Kits

PTK7 Antibodies

PTK7 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA018996LA01HU	PTK7 Antibody	Human	ELISA, IHC
CSB-PA018996LC01HU	PTK7 Antibody, FITC conjugated	Human
CSB-PA018996LD01HU	PTK7 Antibody, Biotin conjugated	Human	ELISA

PTK7 Proteins

PTK7 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP622651HU	Recombinant Human Inactive tyrosine-protein kinase 7 (PTK7), partial	Yeast
CSB-EP622651HU CSB-BP622651HU CSB-MP622651HU CSB-EP622651HU-B	Recombinant Human Inactive tyrosine-protein kinase 7 (PTK7), partial	E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-MP622651HU2	Recombinant Human Inactive tyrosine-protein kinase 7(PTK7),partial (Active)	Mammalian cell

PTK7 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP804364MO	Recombinant Mouse Inactive tyrosine-protein kinase 7 (Ptk7), partial,Yeast	Yeast
CSB-EP804364MO CSB-BP804364MO CSB-MP804364MO CSB-EP804364MO-B	Recombinant Mouse Inactive tyrosine-protein kinase 7 (Ptk7), partial	E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PTK7 Proteins for Gallus gallus (Chicken)

Code	Product Name	Source
CSB-YP835490CH CSB-EP835490CH CSB-BP835490CH CSB-MP835490CH CSB-EP835490CH-B	Recombinant Chicken Inactive tyrosine-protein kinase 7 (PTK7), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PTK7 ELISA Kit

PTK7 ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-EL018996HU	Human Inactive tyrosine-protein kinase 7(PTK7) ELISA kit	serum, plasma, tissue homogenates, cell lysates	3.125 pg/mL

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PTK7

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