SCN1A is a crucial ion channel protein composed of a large pore-forming α-subunit and multiple small β-subunits, primarily expressed in the brain and peripheral nerves. As part of the voltage-gated sodium channel, SCN1A plays a pivotal role in regulating neurotransmitter release and mechanosensory pain perception. The voltage-sensing domain and pore of its structure jointly regulate the depolarization process, affecting neuronal excitability. When neurons are stimulated, the SCN1A channel opens, triggering action potentials and participating in the transmission of neural signals. However, mutations in SCN1A can lead to abnormal channel function, which may subsequently cause neurological disorders such as epilepsy. Therefore, a deep investigation into the structural function and signaling pathways of SCN1A is crucial for enhancing our understanding of the working principles of the nervous system and the pathogenesis of related diseases.
Recombinant Human Repulsive guidance molecule A (RGMA)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
The following SCN1A reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
SCN1A Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA409848 | SCN1A Antibody |
Human,Rat | ELISA,IHC |
CSB-PA044197 | SCN1A Antibody |
Human,Rat | ELISA,IHC |
CSB-PA020834ESR1HU | SCN1A Antibody |
Human | ELISA |
SCN1A Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP020834HU CSB-MP020834HU CSB-EP020834HU-B |
Recombinant Human Sodium channel protein type 1 subunit alpha (SCN1A), partial |
Yeast Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP020834HU | Recombinant Human Sodium channel protein type 1 subunit alpha (SCN1A), partial |
E.coli |
CSB-BP020834HU | Recombinant Human Sodium channel protein type 1 subunit alpha (SCN1A), partial |
Baculovirus |