SLC34A2

SLC34A2, solute carrier family 34 member A2, alias sodium-phosphate cotransporter protein 2" (NaPi2)/renal phosphate reabsorption protein, etc. SLC34A2 is a transmembrane protein expressed on cell membranes and is a member of the SLC34 family, which functions mainly in the kidney, small intestine and some tumour cells. Its mechanism of action involves sodium-dependent phosphate transport, which facilitates the reabsorption of phosphate from urine or intestinal lumen into the bloodstream through co-transport with sodium ions.The activity of SLC34A2 is regulated by a variety of factors, including pH, extracellular phosphate and sodium ion concentrations, and this regulatory role is essential for maintaining phosphate homeostasis in vivo.

The biological significance of SLC34A2 is mainly reflected by its effect on the regulation of phosphate homeostasis. It is involved in the process of phosphate absorption and reabsorption in the body, and has an important impact on bone health, cell signalling, energy metabolism, etc. Abnormal function of SLC34A2 is associated with disorders of phosphate metabolism, such as hypophosphatemia, rickets, osteochondrosis, and other disorders of phosphate metabolism. In addition, the expression of SLC34A2 in the tumour microenvironment may be related to the invasiveness and metastatic ability of tumours, making it a potential target in cancer research and therapy.