SLC7A11

SLC7A11, solute carrier family 7 member 11, cystine/glutamate transporter，also known as xCT, CCBR1. The protein encoded by SLC7A11 is a key component of the cystine/glutamate reverse transporter (SystemXc-), which is primarily responsible for transporting extracellular cystine into the cell in exchange for glutamate. This process is essential for maintaining intracellular glutathione (GSH) levels and protecting cells from oxidative stress-induced cell death.
SLC7A11 is not only associated with nutrient-dependent and oxidative stress responses in cells, but also a potential target for tumor therapy. SLC7A11 is highly expressed in a variety of tumors and is closely associated with tumor growth, prognosis, metastasis and treatment. High expression of SLC7A11 increases the sensitivity of tumor cells to oxidative stress stimuli and may promote tumor growth by inhibiting iron death.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human SLC7A11 at 2μg/mL can bind Anti-SLC7A11 recombinant antibody (CSB-RA892171MA1HU), the EC₅₀ is 9.452-13.79 ng/mL.

Loaded Anti-Human SLC7A11 Antibody (CSB-RA892171MA1HU) on 96-Flat plate, can bind Human SLC7A11, with an affinity constant of ＜1 pM as determined in BLI assay (Gator Prime).

SLC7A11 Antibody (CSB-PA145393)

Validated Data

The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA145393(SLC7A11 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA145393(SLC7A11 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)

Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: K562 and hepg2 cell, Primary antibody: CSB-PA145393(SLC7A11 Antibody) at dilution 1/300 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds

The following SLC7A11 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

SLC7A11 Antibodies

SLC7A11 Proteins

SLC7A11 Antibodies

SLC7A11 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA145393	SLC7A11 Antibody	Human,Mouse	ELISA,WB,IHC
CSB-RA892171MA1HU	SLC7A11 Recombinant Monoclonal Antibody	Human	ELISA

SLC7A11 Proteins

SLC7A11 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP894813MO CSB-EP894813MO CSB-BP894813MO CSB-MP894813MO CSB-EP894813MO-B	Recombinant Mouse Cystine/glutamate transporter (Slc7a11), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SLC7A11 Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

Code	Product Name	Source
CSB-YP735762PYX CSB-EP735762PYX CSB-BP735762PYX CSB-MP735762PYX CSB-EP735762PYX-B	Recombinant Pongo abelii Cystine/glutamate transporter (SLC7A11), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SLC7A11 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP892171HU CSB-EP892171HU CSB-BP892171HU CSB-MP892171HU CSB-EP892171HU-B	Recombinant Human Cystine/glutamate transporter (SLC7A11), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF892171HU(A4)	Recombinant Human Cystine/glutamate transporter (SLC7A11) (Active)	in vitro E.coli expression system
CSB-MP892171HU(A4)	Recombinant Human Cystine/glutamate transporter (SLC7A11)-VLPs	Mammalian cell

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SLC7A11

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