SMAD3 Research Reagents

Mothers against decapentaplegic homolog 3 is a protein in humans that is encoded by SMAD3 gene. Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive.

The following SMAD3 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

SMAD3 Antibodies

SMAD3 Antibodies for Homo sapiens (Human)

SMAD3 Antibodies for Mus musculus (Mouse)

SMAD3 Proteins

SMAD3 Proteins for Homo sapiens (Human)

SMAD3 Proteins for Rattus norvegicus (Rat)

SMAD3 Proteins for Gallus gallus (Chicken)

SMAD3 Proteins for Sus scrofa (Pig)

SMAD3 Proteins for Mus musculus (Mouse)

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