SMAD4

Mothers against decapentaplegic homolog 4 is a protein in humans that is encoded by SMAD4 gene. In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (By similarity). Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling.

SMAD4 Antibodies

SMAD4 Antibodies for Homo sapiens (Human)

SMAD4 Antibodies for Human

SMAD4 Proteins

SMAD4 Proteins for Mus musculus (Mouse)

SMAD4 Proteins for Rattus norvegicus (Rat)

SMAD4 Proteins for Homo sapiens (Human)

SMAD4 Proteins for Bos taurus (Bovine)

SMAD4 Proteins for Sus scrofa (Pig)

SMAD4 cDNA for Homo sapiens (Human)

Code Product Name Vector Accession NO.
CSB-CL619768HU1 SMAD4 pUC NM_005359.5

SMAD4 cDNA for Bos taurus (Bovine)

Code Product Name Vector Accession NO.
CSB-CL627061BO SMAD4 pUC NM_001076209.1

SMAD4 cDNA for Sus scrofa (Pig)

Code Product Name Vector Accession NO.
CSB-CL884388PI SMAD4 pUC NM_214072.1

SMAD4 ELISA Kit

SMAD4 ELISA Kit for Homo sapiens (Human)

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