TMIGD2

TMIGD2, the transmembrane immunoglobulin structural domain-containing 2 protein, is a glycoprotein that is predominantly expressed in a variety of cell types, including tumour cells and immune cells.The mechanism of action of TMIGD2 involves cell-cell interactions, cell migration and angiogenesis. Its interaction with HHLA2 enhances T cell proliferation and cytokine production via AKT-dependent signalling during T cell receptor-mediated activation. In terms of signalling pathways, TMIGD2 may be involved in the activation of the JAK/STAT signalling pathway, which is particularly important in hepatocellular carcinoma, and HHLA2 activates this signalling pathway by binding to TMIGD2, thereby affecting the proliferation and survival of tumour cells. In biological significance, TMIGD2 is not only involved in the basic physiological processes of cells, but may also act as a regulator of tumour invasive and metastatic ability, which has the prospect of application as a drug target or biomarker.