TRAF6

TNF receptor-associated factor 6 is a protein in humans that is encoded by TRAF6 gene. E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation.

TRAF6 Antibodies

TRAF6 Antibodies for Homo sapiens (Human)

TRAF6 Antibodies for Human

TRAF6 Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)

TRAF6 Proteins

TRAF6 Proteins for Mus musculus (Mouse)

TRAF6 Proteins for Sus scrofa (Pig)

TRAF6 Proteins for Rattus norvegicus (Rat)

TRAF6 Proteins for Macaca mulatta (Rhesus macaque)

TRAF6 Proteins for Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)

TRAF6 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

TRAF6 Proteins for Homo sapiens (Human)

TRAF6 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

TRAF6 Proteins for Bos taurus (Bovine)

TRAF6 ELISA Kit

TRAF6 ELISA Kit for Bos taurus (Bovine)

TRAF6 ELISA Kit for Homo sapiens (Human)

TRAF6 ELISA Kit for Mus musculus (Mouse)

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