Poli Antibody

1. Pol iota occasionally accesses the replication fork to generate a first mutation, and Pol zeta extends the mismatch with a second mutation. PMID: 27455952
2. Mouse DNA polymerase iota lacking exon 2 (42 amino acids) is catalytically inactive in vitro. PMID: 28077247
3. Exon 2 deletion abrogates both the DNA polymerase and dRP lyase activities of Pol iota in the presence of either Mg(2+) or Mn(2+) ions. Thus, 129-derived strains of mice express catalytically inactive alternatively spliced Pol iota variant. PMID: 28077248
4. PolH contributes to accurate translesion synthesis (TLS) past both T- & C-containing dimers. PolI is involved in error-prone TLS past cytosine-containing dimers when Poleta is inactivated. PMID: 25733082
5. Poliota causes the Par2 effect and inhibits tumorigenesis and mutagenesis PMID: 23955086
6. in mammalian cells, both polymerases kappa and iota are necessary for the error-free bypass of N(2)-CEdG and N(2)-CMdG. PMID: 21454642
7. Upon DNA damage, the UBDs (UBM domains) of polymerase iota (Pol iota) interact with ubiquitinated proliferating cell nuclear antigen to regulate the interchange between processive DNA polymerases and translesional synthesis PMID: 20929865
8. In the presence of Mg2+, the enzyme was active only in testicles and brain, whereas in the presence of Mn2+ the activity was found in all organs. PMID: 20673215
9. Data suggest that either DNA polymerase iota does not participate in hypermutation, or its role is nonessential and can be readily assumed by another low-fidelity polymerase. PMID: 12925679
10. Nucleotide polymorphisms in DNA polymerase iota is associated with lung tumorigenesis in mouse and humans PMID: 15026325
11. Pol kappa and Pol iota double-deficient mice had the normal somatic hypermutation frequency PMID: 15860226
12. Pol iota gene may participate in error-free repair of damaged DNA and prevention of lung tumor development PMID: 15904465
13. identification of two previously unknown ubiquitin-binding domains in the Y-family translesion synthesis polymerases that enable them to interact with monoubiquitinated targets and undergo monoubiquitination in vivo PMID: 16357261
14. suggest the involvement of the Pol eta and Pol iota proteins in UV-induced skin carcinogenesis PMID: 17015482
15. Although pol iota deficiency alone had no effect, UV-induced skin tumors in pol eta-deficient mice developed 4 weeks earlier in mice concomitantly deficient in pol iota PMID: 17114294

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KEGG: mmu:26447

STRING: 10090.ENSMUSP00000112563

UniGene: Mm.244352