Recombinant Mouse B-lymphocyte antigen CD19 (Cd19), partial

1. The results suggest that CD19 controls the differentiation of marginal zone precursors to marginal zone B cells by regulating ADAM28-mediated Notch2 cleavage. PMID: 28707394
2. This study demonstrates that antiviral protective antibody-secreting cells (ASC) in the central nervous system are dependent on CD19 activation and peripheral Germinal Center formation, while accumulation of early-recruited IgD(+) B cells is CD19 independent. PMID: 28931676
3. this study shows that mitochondrial reactive oxygen species suppress humoral immune responses through reduction of CD19 expression and resultant B cell receptor signaling in B cells PMID: 27883180
4. autoimmunity induced by excessive BAFF production requires B1b B cells and CD19 signaling. PMID: 26103922
5. WIPF1 deficiency impaired CD19 co-receptor activation and subsequent PI3 kinase signaling, by distorting the actin and tetraspanin networks that lead to altered CD19 cell surface dynamics. PMID: 26453379
6. Syk-deficient B cells require BAFF receptor and CD19/PI3K signaling for their long-term survival. PMID: 25630702
7. The selection of mature B cells is critically dependent on the expression level of the co-receptor CD19. PMID: 24472602
8. This inhibitory function of FcgammaRIIB in impairing the spatial-temporal colocalization of BCR and CD19 microclusters in the B cell immunological synapse may help explain the hyper-reactive features of systemic lupus erythematosus PMID: 24790152
9. These results show that the ability of CD19-CAR T-cells to home in on tumor lesions is pivotal for their anti-tumor effects in our xenograft models, and therefore may enhance the efficacy of adoptive T-cell therapy for refractory B-cell lymphoma. PMID: 23872144
10. Data show that effective B cell receptor (BCR) signaling requires collaboration with the coreceptor CD19 organized by the CD81-tetraspanin network. PMID: 23499492
11. results indicate that the CD19/CD81 complex interacts with CD38 but this interaction is not required to induce proliferation in mouse B lymphocytes PMID: 22564057
12. CD19positive CD45R(lo)positive lymphocytes of embryonic origin are present in Peyer's patches and in the spleen throughout the life span of wild-type mice, beginning at postnatal day 7. PMID: 22837485
13. We report that regulatory dendritic cells can induce splenic B cells to differentiate into a distinct subtype of IL-10-producing regulatory B cells with unique phenotype CD19(hi)FcgammaIIb(hi). PMID: 22692512
14. CD19 is a major BCR-independent regulator of MYC-driven neoplastic growth in B cell neoplasms. PMID: 22546857
15. Data from transgenic/knockout mice indicate that CD19 is not required for generation of marginal zone B-cells under influence of Notch2 signaling; data confirm that in absence of CD19, all B cells shift to marginal zone B-cell compartment. PMID: 21795747
16. Adoptive transfer of syngeneic T cells transduced with a chimeric antigen receptor that recognizes CD19 can eradicate lymphoma and normal B cells. PMID: 20631379
17. CD19 expression has both protective and disease promoting roles in lupus pathogenesis in New Zealand black (NZB) and in New Zealand white F1 hybrid (NZB/W) mice deficient for CD19 (CD19-/-). PMID: 20368271
18. BCR engagement induced differential Tyr phosphorylation. Y(513) phophorylation occurred 1st; Y(482) phosphorylation was delayed & transient. This affected CD19-mediated downstream pathways. Phosphorylation differed with the plasma membrane location. PMID: 20101619
19. Ca(2+) down-regulates SLC and CD19 gene expression upon pre-BCR activation through inhibition of E2A by Ca(2+)/calmodulin. PMID: 20022378
20. CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse PMID: 12045259
21. The physiologic role of eight CD19 tyrosines was examined in CD19-knockout mice expressing transgenic CD19 constructs. PMID: 12387743
22. The CD19 B-cell signaling pathway is required for replication of the LP-BM5 mixture of murine leukemia viruses in genetically susceptible mice and subsequent development of lymphadenopathy and immunodeficiency. PMID: 12421939
23. CD19 phosphorylation after B cell receptor ligation is found to be unaffected by the absence of Lyn, yet dependent on Src family protein tyrosine kinases, as it is inhibited fully by an Src family-specific inhibitor. PMID: 12471124
24. Modulation of cell survival is a key property of the function of the B cell coreceptor CD19 in vivo and accounts for some of the phenotypes observed in CD19-/- knockout mice. PMID: 12496385
25. CD19 contributes to B cell generation at the early antigen-independent stages of B cell development, in addition to important roles in the peripheral immune system. PMID: 14634103
26. editing, immature 3-83Tg B cells deficient of CD19 have elevated BCR tonic signals and that lowering these tonic signals effectively suppresses receptor editing. PMID: 14668327
27. CD19 has an important function in regulating positive selection and maturation of nontransgenic B-cell precursors PMID: 15644414
28. CD19(-/-) mice generated B-1b cells and protective adaptive PPS-specific antibody responses, whereas hCD19Tg mice lacked B-1b cells and adaptive PPS-specific antibody responses. PMID: 16039575
29. Susceptibility to collagen-induced arthritis requires CD19 on B cells. PMID: 16210644
30. CD19-/- mice have a marked loss of peritoneal B-1 cells, hyporesponsive to mitogens and BCR ligation. PMID: 16227086
31. streptavidin-C3dg enhancement of BCR-induced [Ca2+]i responses required CD21 and CD19 expression and resulted in significantly enhanced CD19 and Lyn phosphorylation, with enhanced Lyn/CD19 associations PMID: 16339538
32. These findings show that Vav1 and PI3K regulation of PLCgamma contributes to the activation of PKD in response to BCR and or CD19 cross-linking. PMID: 16380231
33. CD19 modulates the Th1/Th2 cytokine balance in B cells and plays a critical role as a suppressive molecule in the development of experimental autoimmune encephalomyelitis. PMID: 16507897
34. requirements of PI3K subunits for BCR or BCR/CD19-induced ERK activation PMID: 16802598
35. in-vivo experiments using anti-CD19 immunotoxin (IT) with vincristine prolonged the survival of mice PMID: 17107913
36. CD19 expression in B cells is critical for termination of contact hypersensitivity responses, possibly through the function of regulatory B cells. PMID: 17556590
37. CD19 may be the signaling intermediate in B cells activated by CD86 proximal to phosphatidylinositol 3-kinase (PI3K). PMID: 17641017
38. BCAP and CD19 have complementary roles in BCR-mediated phosphoinositide 3-kinase activation PMID: 18025150
39. There is an essential role for CD19, independent of the costimulatory molecule CD21, in amplifying early B cell activation events in response to membrane-bound ligand stimulation. PMID: 18059271
40. CD19 deficiency suppresses fibrosis and autoantibody production by inhibiting TLR4 signals. PMID: 18467694
41. identified a B cell-specific upstream enhancer and showed that the developmental regulation of Cd19 expression involves precisely coordinated alterations in transcription factor binding and chromatin remodeling at Cd19 cis-regulatory elements. PMID: 18552207
42. NK cells in the CD19- B220+ bone marrow fraction are increased in senescence and reduce E2A and surrogate light chain proteins in B cell precursors. PMID: 19428458
43. deficiency of marginal zone B cells in CD19(-/-) mice is caused by a defect of intrinsic B cell signaling PMID: 19494255
44. Findings suggest a defect in CD19-mediated signals in both peritoneal and splenic B-1 B lymphocytes, which is in part, due to higher levels of constitutively active Lyn. PMID: 19541367
45. Findings confirm the importance of interaction of CRs CD21 and CD35 and CD19 for coreceptor activity in humoral immunity but identify a role for CRs in B-cell memory independent of CD19. PMID: 19706534
46. CD21/35 promotes protective humoral immunity to S. pneumoniae and other strong TI-2 Ags through a complement-independent pathway by negatively regulating CD19 expression and PD-1 induction PMID: 19710450
47. This molecule functions synergistically with the CD21 antigen to enhance signaling through the B cell antigen receptor in response to T cell-dependent, complement-tagged antigens. PMID: 11418645

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KEGG: mmu:12478

STRING: 10090.ENSMUSP00000032968

UniGene: Mm.4360