Code | CSB-RA240597A0HU |
Size | US$210 |
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Application | Recommended Dilution |
---|---|
WB | 1:500-1:5000 |
IHC | 1:50-1:200 |
PDCD1, also known as PD1, is an inhibitory receptor expressed by all T cells during activation. During numerous physiological reactions, including as acute and chronic infection, cancer and autoimmunity, and immunological homeostasis, it modulates T cell effector functions. PDL1 interacts with PD1, limiting cytokine production and triggering apoptosis in PD1 positive cells. Within the tumor microenvironment, the PD1-PDL1 pathway regulates the establishment and maintenance of immune tolerance. In cancer, PD1 and its ligands PDL1 and PDL2 are responsible for T cell activation, proliferation, and cytotoxic secretion, all of which contribute to the degeneration of anti-tumor immune responses.
Mammalian cells are transfected with plasma vectors containing PDCD1 antibody genes, allowing for both recombinant PDCD1 antibody expression and secretion to the medium. Collecting the cell supernatant and purifying to obtain the recombinant PDCD1 antibody by Affinity-chromatography. This recombinant PDCD1 antibody has been validated to detect the PDCD1 protein of Human in the ELISA, WB, IHC.There are currently no reviews for this product.