ALPI

The gene ALPI encodes alkaline phosphatase, intestinal (ALPI), a hydrolase enzyme primarily expressed in the small intestine epithelium. Its main function is dephosphorylating various substrates, aiding in nutrient absorption and mucosal barrier maintenance. ALPI is also known as intestinal alkaline phosphatase or IAP.
ALPI modulates gut microbiota homeostasis and inflammation by dephosphorylating lipopolysaccharides, thereby regulating TLR4-NF-κB signaling pathways. Dysregulation is linked to inflammatory bowel disease and colorectal cancer. Current research explores ALPI supplementation as a potential therapy for gut inflammation and sepsis, with preclinical studies showing promising results in reducing intestinal permeability and systemic inflammation.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ALPI Antibody (CSB-PA11989A0Rb)

Validated Data

Western blot
All lanes: ALPI antibody at 2µg/ml + 293T whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 57 kDa
Observed band size: 57 kDa

Human Intestinal-type alkaline phosphatase,ALPI ELISA Kit (CSB-E09709h)

Validated Data

Code: CSB-E09709h

Size: 96T,5×96T,10×96T

Sensitivity: 0.78 ng/mL

Detection Range: 3.12 ng/mL-200 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

The following ALPI reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

ALPI Antibodies

ALPI Proteins

ALPI ELISA Kits

ALPI Antibodies

ALPI Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA11989B0Rb	ALPI Antibody, HRP conjugated	Human	ELISA
CSB-PA11989A0Rb	ALPI Antibody	Human	ELISA, WB
CSB-PA921124	ALPI Antibody	Human	ELISA,IHC

ALPI Proteins

ALPI Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP001627BO CSB-EP001627BO CSB-BP001627BO CSB-MP001627BO CSB-EP001627BO-B	Recombinant Bovine Intestinal-type alkaline phosphatase (ALPI)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ALPI Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-EP001627RA CSB-BP001627RA CSB-EP001627RA-B	Recombinant Rat Intestinal-type alkaline phosphatase 1 (Alpi)	E.coli Baculovirus In Vivo Biotinylation in E.coli
CSB-YP001627RA	Recombinant Rat Intestinal-type alkaline phosphatase 1 (Alpi)	Yeast
CSB-MP001627RA	Recombinant Rat Intestinal-type alkaline phosphatase 1 (Alpi) (Active)	Mammalian cell

ALPI Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP001627HU	Recombinant Human Intestinal-type alkaline phosphatase (ALPI)	Yeast
CSB-BP001627HU CSB-EP001627HU-B	Recombinant Human Intestinal-type alkaline phosphatase (ALPI)	Baculovirus In Vivo Biotinylation in E.coli
CSB-EP001627HU1	Recombinant Human Intestinal-type alkaline phosphatase (ALPI), partial	E.coli
CSB-YP001627HU1 CSB-EP001627HU1 CSB-BP001627HU1 CSB-MP001627HU1 CSB-EP001627HU1-B	Recombinant Human Intestinal-type alkaline phosphatase (ALPI), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP001627HU	Recombinant Human Intestinal-type alkaline phosphatase (ALPI)	E.coli
CSB-MP001627HU	Recombinant Human Intestinal-type alkaline phosphatase (ALPI) (Active)	Mammalian cell

ALPI ELISA Kit

ALPI ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-E09709h	Human Intestinal-type alkaline phosphatase,ALPI ELISA Kit	serum, plasma, tissue homogenates	0.78 ng/mL

Promotions

Popular Pathways

Apoptosis

Breast Cancer

Autophagy

Hippo Signaling Pathway

Wnt Signaling Pathway

Hippo signaling pathway

TGF-beta signaling pathway

Apoptosis mediated by mitochondria The Overview of Hippo Signaling Pathway The Overview of Autophagy Crosstalk Between Autophagy and Apoptosis The Overview of Wnt Signaling Pathway The Overview of Breast Cancer: Related Signaling Pathways, Therapeutic Targets The overview of TGF-β signaling pathway PI3K-Akt Signaling Pathway and Cancer Apoptosis mediated by endoplasmic reticulum Apoptosisi mediated by death receptor Aesthetic Appreciation of Apoptosis Signal Pathway An Overview of Cell Death: Necrosis and Apoptosis Do You Really Know TGF-β Superfamily? Double-Edged Sword: TGF-β The Overview of PI3-Alt Signaling Pathway How to Inquire and Utilize the Signal Pathway on KEGG LPS/TLR4 Signal Transduction Pathway Epigenetic Histone Modifications Pathway What A Paradoxical TNF Signaling Pathway-Based on Different Receptors The Overview of Fc Receptors- Classification, Related Signaling Pathways and Application

ALPI

Popular Product: