CCR1

CCR1, chemokine receptor 1, is a G protein-coupled receptor (GPCR) found in myeloid cells like monocytes, macrophages, and select T and B cells. This receptor initiates signaling cascades upon ligand binding, activating pathways such as phospholipase C (PLC) and adenylate cyclase (AC), which modulate intracellular calcium, inositol triphosphate (IP3), and cAMP levels, ultimately driving cell chemotaxis and functional alterations. Central to immune and inflammatory responses, CCR1 facilitates the migration of immune cells to sites of inflammation, aiding in pathogen elimination and tissue restoration. Its dysregulation is implicated in diseases like asthma, atherosclerosis, multiple sclerosis, and certain cancers, making the CCR1-ligand interaction a significant factor in disease pathogenesis and a promising target for therapeutic intervention.