CCR1, also known as C-C chemokine receptor type 1, is a protein with an alternative name of CMKBR1. It belongs to the G - protein - coupled receptor family. CCR1 binds to multiple chemokines, initiating signaling cascades upon ligand binding. This receptor is involved in the regulation of immune cell migration and activation. The signaling pathway related to CCR1 mainly includes the activation of downstream kinases through the G - protein - mediated mechanism.
CCR1 has been implicated in various diseases, such as multiple sclerosis, rheumatoid arthritis, and some types of cancer. In drug development, efforts are underway to design specific CCR1 antagonists to block its function. These antagonists are expected to provide novel therapeutic options for CCR1 - associated diseases.
Recombinant Human C-C chemokine receptor type 1 (CCR1)-VLPs (Active) (CSB-MP004839HU)
Validated Data
CSB-MP004839HU is detected by Mouse anti-6*His monoclonal antibody.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CCR1 at 10 μg/ml can bind Anti-CCR1 recombinant antibody(CSB-RA004839MA1HU). The EC50 is 9.690-10.94 ng/mL.The VLPs (CSB-MP3838) is negative control.
The purity of VLPs was greater than 90% as determined by SEC-HPLC
Recombinant Human C-C chemokine receptor type 1 (CCR1), partial (CSB-EP004839HU1)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CCR1 Antibody (CSB-PA004839LA01HU)
Validated Data
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA004839LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA004839LA01HU at dilution of 1:100
Immunofluorescent analysis of U251 cells using CSB-PA004839LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
The following CCR1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
CCR1 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA004839LA01HU | CCR1 Antibody | Human | ELISA, IHC, IF |
CCR1 Antibodies for Arabidopsis thaliana (Mouse-ear cress)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA879677XA01DOA | CCR1 Antibody | Arabidopsis thaliana | ELISA, WB (ensure identification of antigen) |
CSB-PA108622XA01DOA | CCR1 Antibody | Arabidopsis thaliana | ELISA, WB (ensure identification of antigen) |
CCR1 Antibodies for Oryza sativa subsp. japonica (Rice)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA561580XA01OFG | CCR1 Antibody | Oryza sativa subsp. japonica (Rice) | ELISA, WB (ensure identification of antigen) |
CCR1 Antibodies for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA018378XA01SXV | ccr1 Antibody | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) | ELISA, WB (ensure identification of antigen) |
CCR1 Proteins for Arabidopsis thaliana (Mouse-ear cress)
Code | Product Name | Source |
---|---|---|
CSB-YP879677DOA CSB-EP879677DOA CSB-BP879677DOA CSB-MP879677DOA CSB-EP879677DOA-B |
Recombinant Arabidopsis thaliana Serine/threonine-protein kinase-like protein CCR1 (CCR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCR1 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-CF004839HU | Recombinant Human C-C chemokine receptor type 1 (CCR1) | in vitro E.coli expression system |
CSB-YP004839HU1 CSB-BP004839HU1 CSB-MP004839HU1 CSB-EP004839HU1-B |
Recombinant Human C-C chemokine receptor type 1 (CCR1), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP004839HU1 | Recombinant Human C-C chemokine receptor type 1 (CCR1), partial | E.coli |
CSB-MP004839HU | Recombinant Human C-C chemokine receptor type 1 (CCR1)-VLPs (Active) | Mammalian cell |
CCR1 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-CF004839MO | Recombinant Mouse C-C chemokine receptor type 1 (Ccr1) | in vitro E.coli expression system |
CSB-YP004839MO1 CSB-EP004839MO1 CSB-BP004839MO1 CSB-MP004839MO1 CSB-EP004839MO1-B |
Recombinant Mouse C-C chemokine receptor type 1 (Ccr1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCR1 Proteins for Macaca mulatta (Rhesus macaque)
Code | Product Name | Source |
---|---|---|
CSB-CF004839MOW | Recombinant Macaca mulatta (Rhesus macaque) C-C chemokine receptor type 1 (CCR1) | in vitro E.coli expression system |
CSB-YP004839MOW1 CSB-EP004839MOW1 CSB-BP004839MOW1 CSB-MP004839MOW1 CSB-EP004839MOW1-B |
Recombinant Macaca mulatta (Rhesus macaque) C-C chemokine receptor type 1 (CCR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCR1 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Code | Product Name | Source |
---|---|---|
CSB-CF018378SXV | Recombinant Schizosaccharomyces pombe NADPH--cytochrome P450 reductase (ccr1) | in vitro E.coli expression system |
CSB-YP018378SXV1 CSB-EP018378SXV1 CSB-BP018378SXV1 CSB-MP018378SXV1 CSB-EP018378SXV1-B |
Recombinant Schizosaccharomyces pombe NADPH--cytochrome P450 reductase (ccr1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCR1 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Code | Product Name | Source |
---|---|---|
CSB-YP650508MOV CSB-EP650508MOV CSB-BP650508MOV CSB-MP650508MOV CSB-EP650508MOV-B |
Recombinant Macaca fascicularis C-C chemokine receptor type 1 (CCR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |