CCR9

C-C chemokine receptor type 9 (CCR9), also known as CD199, is a G protein-coupled receptor (GPCR) that binds its ligand CCL25 (thymus-expressed chemokine, TECK). Its activation via Gαi/o signaling triggers calcium mobilization, MAPK pathway activation, and chemotaxis of T cells to intestinal mucosa, regulating mucosal immune homeostasis.
CCR9 is implicated in inflammatory bowel diseases (IBD) like Crohn’s disease and ulcerative colitis, as its signaling drives pathological immune cell infiltration. It also links to enteropathy-associated T-cell lymphoma. Small-molecule antagonists such as vercirnon (CCX282-B) have reached phase III trials for Crohn’s disease, targeting to block CCR9-CCL25 interaction and reduce gut inflammation.

Validated Data

CSB-MP004848HU is detected by Mouse anti-6*His monoclonal antibody.

The purity of VLPs was greater than 95% as determined by HPLC-SEC.

Measured by its binding ability in a functional ELISA. Immobilized Human CCR9 at 10μg/mL can bind Anti-CCR9 recombinant antibody (CSB-RA004848MA1HU)，the EC₅₀ is 31.67-36.83 ng/mL.The VLPs (CSB-MP3838) is negative control.

Recombinant Human C-C chemokine receptor type 9 (CCR9), partial (CSB-EP004848HU1)

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CCR9 Recombinant Monoclonal Antibody (CSB-RA004848MA1HU)

Validated Data

The Binding Activity of CCR9 with Anti-CCR9 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CCR9 at 10 μg/mL can bind Anti-CCR9 recombinant antibody (CSB-RA004848MA1HU). The EC₅₀ is 31.67-36.83 ng/mL.The VLPs (CSB-MP3838) is negative control.

Untransfected MC38 cells (green line) and transfected Human CCR9 MC38 stable cells (red line) were stained with anti-CCR9 antibody (CSB-RA004848MA1HU) (2µg/1*106cells), washed and then followed by APC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

The following CCR9 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

CCR9 Antibodies

CCR9 Proteins

CCR9 Antibodies

CCR9 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA035070	CCR9 Antibody	Human,Mouse	ELISA,IHC
CSB-PA293047	CCR9 Antibody	Human,Mouse	ELISA,IHC
CSB-RA004848A0HU	CCR9 Recombinant Monoclonal Antibody	Human	ELISA, IF
CSB-RA004848MA1HU	CCR9 Recombinant Monoclonal Antibody	Human	ELISA, FC

CCR9 Proteins

CCR9 Proteins for Ovis aries (Sheep)

Code	Product Name	Source
CSB-CF631240SH	Recombinant Sheep C-C chemokine receptor type 9 (CCR9)	in vitro E.coli expression system
CSB-YP631240SH1 CSB-EP631240SH1 CSB-BP631240SH1 CSB-MP631240SH1 CSB-EP631240SH1-B	Recombinant Sheep C-C chemokine receptor type 9 (CCR9), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CCR9 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-CF894369MO	Recombinant Mouse C-C chemokine receptor type 9 (Ccr9)	in vitro E.coli expression system
CSB-YP894369MO1 CSB-EP894369MO1 CSB-BP894369MO1 CSB-MP894369MO1 CSB-EP894369MO1-B	Recombinant Mouse C-C chemokine receptor type 9 (Ccr9), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CCR9 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-CF004848HU	Recombinant Human C-C chemokine receptor type 9 (CCR9)	in vitro E.coli expression system
CSB-YP004848HU1 CSB-BP004848HU1 CSB-MP004848HU1 CSB-EP004848HU1-B	Recombinant Human C-C chemokine receptor type 9 (CCR9), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP004848HU1	Recombinant Human C-C chemokine receptor type 9 (CCR9), partial	E.coli
CSB-MP004848HU	Recombinant Human C-C chemokine receptor type 9 (CCR9)-VLPs (Active)	Mammalian cell

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CCR9

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